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Junin virus activity in rodents from endemic and nonendemic loci in central Argentina.
Am J Trop Med Hyg. 1991 Jun; 44(6):589-97.AJ

Abstract

Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species: Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodon azarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward.

Authors+Show Affiliations

Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1650148

Citation

Mills, J N., et al. "Junin Virus Activity in Rodents From Endemic and Nonendemic Loci in Central Argentina." The American Journal of Tropical Medicine and Hygiene, vol. 44, no. 6, 1991, pp. 589-97.
Mills JN, Ellis BA, McKee KT, et al. Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. Am J Trop Med Hyg. 1991;44(6):589-97.
Mills, J. N., Ellis, B. A., McKee, K. T., Ksiazek, T. G., Oro, J. G., Maiztegui, J. I., Calderon, G. E., Peters, C. J., & Childs, J. E. (1991). Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. The American Journal of Tropical Medicine and Hygiene, 44(6), 589-97.
Mills JN, et al. Junin Virus Activity in Rodents From Endemic and Nonendemic Loci in Central Argentina. Am J Trop Med Hyg. 1991;44(6):589-97. PubMed PMID: 1650148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. AU - Mills,J N, AU - Ellis,B A, AU - McKee,K T,Jr AU - Ksiazek,T G, AU - Oro,J G, AU - Maiztegui,J I, AU - Calderon,G E, AU - Peters,C J, AU - Childs,J E, PY - 1991/6/11/pubmed PY - 2001/3/28/medline PY - 1991/6/11/entrez SP - 589 EP - 97 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 44 IS - 6 N2 - Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species: Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodon azarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/1650148/Junin_virus_activity_in_rodents_from_endemic_and_nonendemic_loci_in_central_Argentina_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.1991.44.589 DB - PRIME DP - Unbound Medicine ER -