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Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas.
Saudi Med J. 2006 Feb; 27(2):161-4.SM

Abstract

OBJECTIVE

To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.

METHODS

This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS

Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant. Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012).

CONCLUSION

The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes.

Authors+Show Affiliations

Department of Gastroenterology, Renmin Hospital, Wuhan University, HuBei, Peoples Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16501668

Citation

Zhongyin, Zhou, et al. "Association of Serum Lipids and Apolipoprotein E Gene Polymorphism With the Risk of Colorectal Adenomas." Saudi Medical Journal, vol. 27, no. 2, 2006, pp. 161-4.
Zhongyin Z, Hesheng L, Jun L, et al. Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. Saudi Med J. 2006;27(2):161-4.
Zhongyin, Z., Hesheng, L., Jun, L., & Jihong, C. (2006). Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. Saudi Medical Journal, 27(2), 161-4.
Zhongyin Z, et al. Association of Serum Lipids and Apolipoprotein E Gene Polymorphism With the Risk of Colorectal Adenomas. Saudi Med J. 2006;27(2):161-4. PubMed PMID: 16501668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. AU - Zhongyin,Zhou, AU - Hesheng,Luo, AU - Jun,Liu, AU - Jihong,Chen, PY - 2006/2/28/pubmed PY - 2006/4/25/medline PY - 2006/2/28/entrez SP - 161 EP - 4 JF - Saudi medical journal JO - Saudi Med J VL - 27 IS - 2 N2 - OBJECTIVE: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas. METHODS: This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant. Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012). CONCLUSION: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/16501668/Association_of_serum_lipids_and_apolipoprotein_E_gene_polymorphism_with_the_risk_of_colorectal_adenomas_ L2 - https://medlineplus.gov/colorectalcancer.html DB - PRIME DP - Unbound Medicine ER -