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Health-related quality of life in multiple system atrophy.
Mov Disord. 2006 Jun; 21(6):809-15.MD

Abstract

Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.

Authors+Show Affiliations

Schrag A
Department of Clinical Neurosciences, Royal Free & University College Medical School, London, United Kingdom.
Geser F
No affiliation info available
Stampfer-Kountchev M
No affiliation info available
Seppi K
No affiliation info available
Sawires M
No affiliation info available
Köllensperger M
No affiliation info available
Scherfler C
No affiliation info available
Quinn N
No affiliation info available
Pellecchia MT
No affiliation info available
Barone P
No affiliation info available
Del Sorbo F
No affiliation info available
Albanese A
No affiliation info available
Ostergaard K
No affiliation info available
Dupont E
No affiliation info available
Cardozo A
No affiliation info available
Tolosa E
No affiliation info available
Nilsson CF
No affiliation info available
Widner H
No affiliation info available
Lindvall O
No affiliation info available
Giladi N
No affiliation info available
Gurevich T
No affiliation info available
Daniels C
No affiliation info available
Deuschl G
No affiliation info available
Coelho M
No affiliation info available
Sampaio C
No affiliation info available
Abele M
No affiliation info available
Klockgether T
No affiliation info available
Schimke N
No affiliation info available
Eggert KM
No affiliation info available
Oertel W
No affiliation info available
Djaldetti R
No affiliation info available
Colosimo C
No affiliation info available
Meco G
No affiliation info available
Poewe W
No affiliation info available
Wenning GK
No affiliation info available
European MSA-Study Group
No affiliation info available

MeSH

AnxietyCohort StudiesDepressionDisability EvaluationEuropeHealth StatusHumansMotor ActivityMultiple System AtrophyPainParkinson DiseaseQuality of LifeSelf CareSurveys and QuestionnairesWhite People

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16502399

Citation

Schrag, Anette, et al. "Health-related Quality of Life in Multiple System Atrophy." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 6, 2006, pp. 809-15.
Schrag A, Geser F, Stampfer-Kountchev M, et al. Health-related quality of life in multiple system atrophy. Mov Disord. 2006;21(6):809-15.
Schrag, A., Geser, F., Stampfer-Kountchev, M., Seppi, K., Sawires, M., Köllensperger, M., Scherfler, C., Quinn, N., Pellecchia, M. T., Barone, P., Del Sorbo, F., Albanese, A., Ostergaard, K., Dupont, E., Cardozo, A., Tolosa, E., Nilsson, C. F., Widner, H., Lindvall, O., ... Wenning, G. K. (2006). Health-related quality of life in multiple system atrophy. Movement Disorders : Official Journal of the Movement Disorder Society, 21(6), 809-15.
Schrag A, et al. Health-related Quality of Life in Multiple System Atrophy. Mov Disord. 2006;21(6):809-15. PubMed PMID: 16502399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life in multiple system atrophy. AU - Schrag,Anette, AU - Geser,Felix, AU - Stampfer-Kountchev,Michaela, AU - Seppi,Klaus, AU - Sawires,Martin, AU - Köllensperger,Martin, AU - Scherfler,Christoph, AU - Quinn,Niall, AU - Pellecchia,Maria T, AU - Barone,Paolo, AU - Del Sorbo,Francesca, AU - Albanese,Alberto, AU - Ostergaard,Karen, AU - Dupont,Erik, AU - Cardozo,Adriana, AU - Tolosa,Eduardo, AU - Nilsson,Christer F, AU - Widner,Håkan, AU - Lindvall,Olle, AU - Giladi,Nir, AU - Gurevich,Tanya, AU - Daniels,Christine, AU - Deuschl,Günther, AU - Coelho,Miguel, AU - Sampaio,Cristina, AU - Abele,Michael, AU - Klockgether,Thomas, AU - Schimke,Nicole, AU - Eggert,Karla M, AU - Oertel,Wolfgang, AU - Djaldetti,Ruth, AU - Colosimo,Carlo, AU - Meco,Giuseppe, AU - Poewe,Werner, AU - Wenning,Gregor K, AU - ,, PY - 2006/2/28/pubmed PY - 2006/11/15/medline PY - 2006/2/28/entrez SP - 809 EP - 15 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 6 N2 - Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16502399/Health_related_quality_of_life_in_multiple_system_atrophy_ DB - PRIME DP - Unbound Medicine ER -