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Health-related quality of life in multiple system atrophy.
Mov Disord. 2006 Jun; 21(6):809-15.MD

Abstract

Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.

Authors+Show Affiliations

Department of Clinical Neurosciences, Royal Free & University College Medical School, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16502399

Citation

Schrag, Anette, et al. "Health-related Quality of Life in Multiple System Atrophy." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 6, 2006, pp. 809-15.
Schrag A, Geser F, Stampfer-Kountchev M, et al. Health-related quality of life in multiple system atrophy. Mov Disord. 2006;21(6):809-15.
Schrag, A., Geser, F., Stampfer-Kountchev, M., Seppi, K., Sawires, M., Köllensperger, M., Scherfler, C., Quinn, N., Pellecchia, M. T., Barone, P., Del Sorbo, F., Albanese, A., Ostergaard, K., Dupont, E., Cardozo, A., Tolosa, E., Nilsson, C. F., Widner, H., Lindvall, O., ... Wenning, G. K. (2006). Health-related quality of life in multiple system atrophy. Movement Disorders : Official Journal of the Movement Disorder Society, 21(6), 809-15.
Schrag A, et al. Health-related Quality of Life in Multiple System Atrophy. Mov Disord. 2006;21(6):809-15. PubMed PMID: 16502399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life in multiple system atrophy. AU - Schrag,Anette, AU - Geser,Felix, AU - Stampfer-Kountchev,Michaela, AU - Seppi,Klaus, AU - Sawires,Martin, AU - Köllensperger,Martin, AU - Scherfler,Christoph, AU - Quinn,Niall, AU - Pellecchia,Maria T, AU - Barone,Paolo, AU - Del Sorbo,Francesca, AU - Albanese,Alberto, AU - Ostergaard,Karen, AU - Dupont,Erik, AU - Cardozo,Adriana, AU - Tolosa,Eduardo, AU - Nilsson,Christer F, AU - Widner,Håkan, AU - Lindvall,Olle, AU - Giladi,Nir, AU - Gurevich,Tanya, AU - Daniels,Christine, AU - Deuschl,Günther, AU - Coelho,Miguel, AU - Sampaio,Cristina, AU - Abele,Michael, AU - Klockgether,Thomas, AU - Schimke,Nicole, AU - Eggert,Karla M, AU - Oertel,Wolfgang, AU - Djaldetti,Ruth, AU - Colosimo,Carlo, AU - Meco,Giuseppe, AU - Poewe,Werner, AU - Wenning,Gregor K, AU - ,, PY - 2006/2/28/pubmed PY - 2006/11/15/medline PY - 2006/2/28/entrez SP - 809 EP - 15 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 6 N2 - Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16502399/Health_related_quality_of_life_in_multiple_system_atrophy_ L2 - https://doi.org/10.1002/mds.20808 DB - PRIME DP - Unbound Medicine ER -