Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis.Ann Neurol 2006; 59(3):499-503AN
To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS).
We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS.
The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.
We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.