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Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis.

Abstract

OBJECTIVE

To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS).

METHODS

We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS.

RESULTS

The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.

INTERPRETATION

We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. ethacker@hsph.harvard.edu

    ,

    Source

    Annals of neurology 59:3 2006 Mar pg 499-503

    MeSH

    Adolescent
    Adult
    Child
    Confidence Intervals
    Epstein-Barr Virus Infections
    Female
    Humans
    Infectious Mononucleosis
    Male
    Multiple Sclerosis
    Odds Ratio
    Retrospective Studies
    Risk
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    16502434

    Citation

    Thacker, Evan L., et al. "Infectious Mononucleosis and Risk for Multiple Sclerosis: a Meta-analysis." Annals of Neurology, vol. 59, no. 3, 2006, pp. 499-503.
    Thacker EL, Mirzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol. 2006;59(3):499-503.
    Thacker, E. L., Mirzaei, F., & Ascherio, A. (2006). Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Annals of Neurology, 59(3), pp. 499-503.
    Thacker EL, Mirzaei F, Ascherio A. Infectious Mononucleosis and Risk for Multiple Sclerosis: a Meta-analysis. Ann Neurol. 2006;59(3):499-503. PubMed PMID: 16502434.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. AU - Thacker,Evan L, AU - Mirzaei,Fariba, AU - Ascherio,Alberto, PY - 2006/2/28/pubmed PY - 2006/5/10/medline PY - 2006/2/28/entrez SP - 499 EP - 503 JF - Annals of neurology JO - Ann. Neurol. VL - 59 IS - 3 N2 - OBJECTIVE: To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS). METHODS: We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS. RESULTS: The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results. INTERPRETATION: We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16502434/full_citation L2 - https://doi.org/10.1002/ana.20820 DB - PRIME DP - Unbound Medicine ER -