Tags

Type your tag names separated by a space and hit enter

Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients.
J Eur Acad Dermatol Venereol 2006; 20(3):260-3JE

Abstract

BACKGROUND

Apolipoprotein E (apoE) phenotypes and lipoprotein compositions in xanthelasma patients have been reported in different series.

OBJECTIVE

To investigate the apoE polymorphism and lipoprotein compositions in xanthelasma patients by using rapid polymerase chain reaction, and searched for an association between apoE polymorphism and the lipoprotein levels in xanthelasma patients.

DESIGN

ApoE polymorphism and the different types of serum lipoproteins were studied in 25 patients with xanthelasma and compared with 27 normal subjects.

RESULTS

All of patients were found to be normolipidaemic. The patients had significantly higher concentrations of total cholesterol and apolipoprotein B, and lower concentrations of apolipoprotein A. There was no difference in serum triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. The distribution of apoE genotypes and alleles was the same in both groups.

CONCLUSIONS

The apoB, apoA and cholesterol levels did show statistically significant differences in the direction of an increased risk of atherosclerosis. Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications.

Authors+Show Affiliations

Department of Dermatology, Faculty of Medicine, Mersin University, Mersin, Turkey. utursen@mersin.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16503883

Citation

Tursen, U, et al. "Apolipoprotein E Polymorphism and Lipoprotein Compositions in Normolipidaemic Xanthelasma Patients." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 20, no. 3, 2006, pp. 260-3.
Tursen U, Eskandari G, Kaya TI, et al. Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients. J Eur Acad Dermatol Venereol. 2006;20(3):260-3.
Tursen, U., Eskandari, G., Kaya, T. I., Tamer, L., Ikizoglu, G., & Atik, U. (2006). Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients. Journal of the European Academy of Dermatology and Venereology : JEADV, 20(3), pp. 260-3.
Tursen U, et al. Apolipoprotein E Polymorphism and Lipoprotein Compositions in Normolipidaemic Xanthelasma Patients. J Eur Acad Dermatol Venereol. 2006;20(3):260-3. PubMed PMID: 16503883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients. AU - Tursen,U, AU - Eskandari,G, AU - Kaya,T I, AU - Tamer,L, AU - Ikizoglu,G, AU - Atik,U, PY - 2006/3/1/pubmed PY - 2006/7/25/medline PY - 2006/3/1/entrez SP - 260 EP - 3 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 20 IS - 3 N2 - BACKGROUND: Apolipoprotein E (apoE) phenotypes and lipoprotein compositions in xanthelasma patients have been reported in different series. OBJECTIVE: To investigate the apoE polymorphism and lipoprotein compositions in xanthelasma patients by using rapid polymerase chain reaction, and searched for an association between apoE polymorphism and the lipoprotein levels in xanthelasma patients. DESIGN: ApoE polymorphism and the different types of serum lipoproteins were studied in 25 patients with xanthelasma and compared with 27 normal subjects. RESULTS: All of patients were found to be normolipidaemic. The patients had significantly higher concentrations of total cholesterol and apolipoprotein B, and lower concentrations of apolipoprotein A. There was no difference in serum triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. The distribution of apoE genotypes and alleles was the same in both groups. CONCLUSIONS: The apoB, apoA and cholesterol levels did show statistically significant differences in the direction of an increased risk of atherosclerosis. Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/16503883/Apolipoprotein_E_polymorphism_and_lipoprotein_compositions_in_normolipidaemic_xanthelasma_patients_ L2 - https://doi.org/10.1111/j.1468-3083.2006.01418.x DB - PRIME DP - Unbound Medicine ER -