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Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.
J Eur Acad Dermatol Venereol 2006; 20(3):277-81JE

Abstract

BACKGROUND

The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers.

METHOD

The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle.

OBJECTIVE

assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks.

RESULTS

A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group.

CONCLUSION

Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers.

Authors+Show Affiliations

Department of Dermatopathology, University Hospital Sart Tilman, Liège, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16503887

Citation

Quatresooz, P, et al. "Healing Effect of Ketanserin On Chronic Leg Ulcers in Patients With Diabetes." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 20, no. 3, 2006, pp. 277-81.
Quatresooz P, Kharfi M, Paquet P, et al. Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. J Eur Acad Dermatol Venereol. 2006;20(3):277-81.
Quatresooz, P., Kharfi, M., Paquet, P., Vroome, V., Cauwenbergh, G., & Piérard, G. E. (2006). Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. Journal of the European Academy of Dermatology and Venereology : JEADV, 20(3), pp. 277-81.
Quatresooz P, et al. Healing Effect of Ketanserin On Chronic Leg Ulcers in Patients With Diabetes. J Eur Acad Dermatol Venereol. 2006;20(3):277-81. PubMed PMID: 16503887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. AU - Quatresooz,P, AU - Kharfi,M, AU - Paquet,P, AU - Vroome,V, AU - Cauwenbergh,G, AU - Piérard,G E, PY - 2006/3/1/pubmed PY - 2006/7/25/medline PY - 2006/3/1/entrez SP - 277 EP - 81 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 20 IS - 3 N2 - BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle. OBJECTIVE: assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks. RESULTS: A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group. CONCLUSION: Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/16503887/Healing_effect_of_ketanserin_on_chronic_leg_ulcers_in_patients_with_diabetes_ L2 - https://doi.org/10.1111/j.1468-3083.2006.01422.x DB - PRIME DP - Unbound Medicine ER -