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Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning.
Neurobiol Learn Mem. 2006 Jul; 86(1):72-81.NL

Abstract

Recent lines of research have focused on dissociating function between the dorsal and ventral hippocampus along space and anxiety dimensions. In the dorsal hippocampus, the CA1 subregion has been implicated in the acquisition of contextual fear as well as in the trace interval in trace fear conditioning. The present study was designed to test the relative contributions of dorsal (dCA1) and ventral CA1 (vCA1) in trace fear conditioning. Long-Evans rats received ibotenate lesions of the ventral CA1 (n=7), dorsal CA1 (n=9), or vehicle control lesions (n=8) prior to trace fear conditioning acquisition. Results suggest dCA1 and vCA1 groups show no significant deficits during acquisition when compared to control groups. dCA1 and vCA1 both show deficits in the retention of contextual fear when tested 24 h post-acquisition (P<.05 and P<.01, respectively), and vCA1 was impaired relative to dCA1 (P<.05). This is suggestive of a graded involvement in contextual retention between the dorsal and ventral aspects of CA1. dCA1 showed no deficit for retention of conditioned fear to the tone or the trace when tested 48 h post-acquisition, whereas vCA1 did show a significant deficit for the trace interval and a slight, non-significant reduction in freezing to the tone, when compared to the control group (p<.05). Overall the data are suggestive of a graded involvement in retention of fear conditioning between the dorsal and ventral aspects of CA1, but it is likely that vCA1 may be critically involved in retention of trace fear conditioning.

Authors+Show Affiliations

Department of Psychology, University of Utah, 380 South 1530 East, Room 502, Salt Lake City, UT 84112-0251, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16504548

Citation

Rogers, Jason L., et al. "Effects of Ventral and Dorsal CA1 Subregional Lesions On Trace Fear Conditioning." Neurobiology of Learning and Memory, vol. 86, no. 1, 2006, pp. 72-81.
Rogers JL, Hunsaker MR, Kesner RP. Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning. Neurobiol Learn Mem. 2006;86(1):72-81.
Rogers, J. L., Hunsaker, M. R., & Kesner, R. P. (2006). Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning. Neurobiology of Learning and Memory, 86(1), 72-81.
Rogers JL, Hunsaker MR, Kesner RP. Effects of Ventral and Dorsal CA1 Subregional Lesions On Trace Fear Conditioning. Neurobiol Learn Mem. 2006;86(1):72-81. PubMed PMID: 16504548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning. AU - Rogers,Jason L, AU - Hunsaker,Michael R, AU - Kesner,Raymond P, Y1 - 2006/02/28/ PY - 2005/10/25/received PY - 2006/01/03/revised PY - 2006/01/12/accepted PY - 2006/3/1/pubmed PY - 2006/8/15/medline PY - 2006/3/1/entrez SP - 72 EP - 81 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 86 IS - 1 N2 - Recent lines of research have focused on dissociating function between the dorsal and ventral hippocampus along space and anxiety dimensions. In the dorsal hippocampus, the CA1 subregion has been implicated in the acquisition of contextual fear as well as in the trace interval in trace fear conditioning. The present study was designed to test the relative contributions of dorsal (dCA1) and ventral CA1 (vCA1) in trace fear conditioning. Long-Evans rats received ibotenate lesions of the ventral CA1 (n=7), dorsal CA1 (n=9), or vehicle control lesions (n=8) prior to trace fear conditioning acquisition. Results suggest dCA1 and vCA1 groups show no significant deficits during acquisition when compared to control groups. dCA1 and vCA1 both show deficits in the retention of contextual fear when tested 24 h post-acquisition (P<.05 and P<.01, respectively), and vCA1 was impaired relative to dCA1 (P<.05). This is suggestive of a graded involvement in contextual retention between the dorsal and ventral aspects of CA1. dCA1 showed no deficit for retention of conditioned fear to the tone or the trace when tested 48 h post-acquisition, whereas vCA1 did show a significant deficit for the trace interval and a slight, non-significant reduction in freezing to the tone, when compared to the control group (p<.05). Overall the data are suggestive of a graded involvement in retention of fear conditioning between the dorsal and ventral aspects of CA1, but it is likely that vCA1 may be critically involved in retention of trace fear conditioning. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/16504548/Effects_of_ventral_and_dorsal_CA1_subregional_lesions_on_trace_fear_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(06)00005-0 DB - PRIME DP - Unbound Medicine ER -