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Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients.
J Diabetes Complications. 2006 Mar-Apr; 20(2):98-104.JD

Abstract

In 70 nonobese inpatients with Type 2 diabetes [body mass index (BMI): 24.0+/-4.4 kg/m(2)], we examined circulating monocyte chemoattractant protein (MCP) -1 as a candidate marker of atherosclerosis by comparison with established markers: serum high-sensitivity C-reactive protein (hsCRP), plasma fibrinogen, and combined carotid artery intimal-medial thickness (IMT). In addition, an association was sought between circulating MCP-1 and urinary albumin excretion (UAE), reflecting diabetic renal microangiopathy. Serum MCP-1 was determined by enzyme-linked immunosorbent assay (ELISA). Patients were grouped by UAE: normoalbuminuria, below 30 mg/g of creatinine (Cr); microalbuminuria, 30 to 300 mg/g Cr; or macroalbuminuria, over 300 mg/g Cr. Serum MCP-1 for all participants, men, and women was 280.0+/-78.9, 269.0+/-68.8, and 294.9+/-87.9 pg/ml, respectively, showing no difference between genders. No correlation was noted between MCP-1 and hsCRP, fibrinogen, or carotid artery IMT. No correlation of MCP-1 was observed with age, duration of diabetes, fasting plasma glucose (FPG), hemoglobin (Hb) A(1C), BMI, diastolic blood pressure (DBP), or serum lipid concentrations, but significant correlations were found with systolic blood pressure (SBP; R=.2723, P=.0225) and with log(10)-transformed (log) UAE (R=.3343, P=.0047). Patients with macroalbuminuria had significant higher circulating MCP-1 than did those with normo- or microalbuminuria (P=.0063 and P=.0188, respectively). By stepwise regression analysis, only log UAE independently predicted serum MCP-1 (beta=.3700, P=.0020). Thus, in nonobese Type 2 diabetic patients, MCP-1 might not be a marker of atherosclerosis and might be influenced significantly by diabetic nephropathy.

Authors+Show Affiliations

Department of Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya 343-8555, Japan. takeb@gmail.plala.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16504838

Citation

Takebayashi, Kohzo, et al. "Association Between Circulating Monocyte Chemoattractant Protein-1 and Urinary Albumin Excretion in Nonobese Type 2 Diabetic Patients." Journal of Diabetes and Its Complications, vol. 20, no. 2, 2006, pp. 98-104.
Takebayashi K, Matsumoto S, Aso Y, et al. Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients. J Diabetes Complications. 2006;20(2):98-104.
Takebayashi, K., Matsumoto, S., Aso, Y., & Inukai, T. (2006). Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients. Journal of Diabetes and Its Complications, 20(2), 98-104.
Takebayashi K, et al. Association Between Circulating Monocyte Chemoattractant Protein-1 and Urinary Albumin Excretion in Nonobese Type 2 Diabetic Patients. J Diabetes Complications. 2006 Mar-Apr;20(2):98-104. PubMed PMID: 16504838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients. AU - Takebayashi,Kohzo, AU - Matsumoto,Sachiko, AU - Aso,Yoshimasa, AU - Inukai,Toshihiko, PY - 2004/08/18/received PY - 2005/05/23/accepted PY - 2006/3/1/pubmed PY - 2006/7/26/medline PY - 2006/3/1/entrez SP - 98 EP - 104 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 20 IS - 2 N2 - In 70 nonobese inpatients with Type 2 diabetes [body mass index (BMI): 24.0+/-4.4 kg/m(2)], we examined circulating monocyte chemoattractant protein (MCP) -1 as a candidate marker of atherosclerosis by comparison with established markers: serum high-sensitivity C-reactive protein (hsCRP), plasma fibrinogen, and combined carotid artery intimal-medial thickness (IMT). In addition, an association was sought between circulating MCP-1 and urinary albumin excretion (UAE), reflecting diabetic renal microangiopathy. Serum MCP-1 was determined by enzyme-linked immunosorbent assay (ELISA). Patients were grouped by UAE: normoalbuminuria, below 30 mg/g of creatinine (Cr); microalbuminuria, 30 to 300 mg/g Cr; or macroalbuminuria, over 300 mg/g Cr. Serum MCP-1 for all participants, men, and women was 280.0+/-78.9, 269.0+/-68.8, and 294.9+/-87.9 pg/ml, respectively, showing no difference between genders. No correlation was noted between MCP-1 and hsCRP, fibrinogen, or carotid artery IMT. No correlation of MCP-1 was observed with age, duration of diabetes, fasting plasma glucose (FPG), hemoglobin (Hb) A(1C), BMI, diastolic blood pressure (DBP), or serum lipid concentrations, but significant correlations were found with systolic blood pressure (SBP; R=.2723, P=.0225) and with log(10)-transformed (log) UAE (R=.3343, P=.0047). Patients with macroalbuminuria had significant higher circulating MCP-1 than did those with normo- or microalbuminuria (P=.0063 and P=.0188, respectively). By stepwise regression analysis, only log UAE independently predicted serum MCP-1 (beta=.3700, P=.0020). Thus, in nonobese Type 2 diabetic patients, MCP-1 might not be a marker of atherosclerosis and might be influenced significantly by diabetic nephropathy. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/16504838/Association_between_circulating_monocyte_chemoattractant_protein_1_and_urinary_albumin_excretion_in_nonobese_Type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(05)00051-6 DB - PRIME DP - Unbound Medicine ER -