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The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye.
Invest Ophthalmol Vis Sci 2006; 47(3):1087-95IO

Abstract

PURPOSE

To document zonular orientation and suspension of the lens during accommodation, and age-related changes of the circumlental space (CLS) at rest and during accommodation, in living iridectomized rhesus monkey eyes.

METHODS

The CLS was measured in 34 iridectomized eyes of 24 living rhesus monkeys, age 5.7 to 26 years, in the resting and accommodated state, and the orientation of the zonula and suspension of the lens during accommodation was assessed qualitatively.

RESULTS

The nonaccommodated CLS decreased significantly with age in both the nasal and temporal quadrants and tended to do so at a slightly faster rate in the temporal quadrant. The CLS correlated significantly with the accommodative amplitude: the greater the CLS the greater the accommodative amplitude. Multiple regression analysis indicated that age and CLS together are better predictors of accommodative amplitude than is age alone. The zonula appeared taut in the nonaccommodated eye throughout the age range despite the age-related decline in CLS.

CONCLUSIONS

Characterization of age-related changes in the accommodative apparatus may help to model the system for hypothesis testing. The CLS may be an indicator of presbyopia-related processes in surrounding tissues. However, these results do not prove that the width of the CLS, in and of itself, has a causal relationship with accommodative amplitude, or that changes in the CLS play a pathophysiological role in presbyopia.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53792-3284, USA. macroft@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16505045

Citation

Croft, Mary Ann, et al. "The Zonula, Lens, and Circumlental Space in the Normal Iridectomized Rhesus Monkey Eye." Investigative Ophthalmology & Visual Science, vol. 47, no. 3, 2006, pp. 1087-95.
Croft MA, Glasser A, Heatley G, et al. The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye. Invest Ophthalmol Vis Sci. 2006;47(3):1087-95.
Croft, M. A., Glasser, A., Heatley, G., McDonald, J., Ebbert, T., Nadkarni, N. V., & Kaufman, P. L. (2006). The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye. Investigative Ophthalmology & Visual Science, 47(3), pp. 1087-95.
Croft MA, et al. The Zonula, Lens, and Circumlental Space in the Normal Iridectomized Rhesus Monkey Eye. Invest Ophthalmol Vis Sci. 2006;47(3):1087-95. PubMed PMID: 16505045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye. AU - Croft,Mary Ann, AU - Glasser,Adrian, AU - Heatley,Gregg, AU - McDonald,Jared, AU - Ebbert,Timothy, AU - Nadkarni,Nivedita V, AU - Kaufman,Paul L, PY - 2006/3/1/pubmed PY - 2006/4/4/medline PY - 2006/3/1/entrez SP - 1087 EP - 95 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 47 IS - 3 N2 - PURPOSE: To document zonular orientation and suspension of the lens during accommodation, and age-related changes of the circumlental space (CLS) at rest and during accommodation, in living iridectomized rhesus monkey eyes. METHODS: The CLS was measured in 34 iridectomized eyes of 24 living rhesus monkeys, age 5.7 to 26 years, in the resting and accommodated state, and the orientation of the zonula and suspension of the lens during accommodation was assessed qualitatively. RESULTS: The nonaccommodated CLS decreased significantly with age in both the nasal and temporal quadrants and tended to do so at a slightly faster rate in the temporal quadrant. The CLS correlated significantly with the accommodative amplitude: the greater the CLS the greater the accommodative amplitude. Multiple regression analysis indicated that age and CLS together are better predictors of accommodative amplitude than is age alone. The zonula appeared taut in the nonaccommodated eye throughout the age range despite the age-related decline in CLS. CONCLUSIONS: Characterization of age-related changes in the accommodative apparatus may help to model the system for hypothesis testing. The CLS may be an indicator of presbyopia-related processes in surrounding tissues. However, these results do not prove that the width of the CLS, in and of itself, has a causal relationship with accommodative amplitude, or that changes in the CLS play a pathophysiological role in presbyopia. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/16505045/The_zonula,_lens,_and_circumlental_space_in_the_normal_iridectomized_rhesus_monkey_eye L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.04-1524 DB - PRIME DP - Unbound Medicine ER -