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The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons.
Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3834-9.PN

Abstract

We report the complete 6,530,228-bp genome sequence of the symbiotic nitrogen fixing bacterium Rhizobium etli. Six large plasmids comprise one-third of the total genome size. The chromosome encodes most functions necessary for cell growth, whereas few essential genes or complete metabolic pathways are located in plasmids. Chromosomal synteny is disrupted by genes related to insertion sequences, phages, plasmids, and cell-surface components. Plasmids do not show synteny, and their orthologs are mostly shared by accessory replicons of species with multipartite genomes. Some nodulation genes are predicted to be functionally related with chromosomal loci encoding for the external envelope of the bacterium. Several pieces of evidence suggest an exogenous origin for the symbiotic plasmid (p42d) and p42a. Additional putative horizontal gene transfer events might have contributed to expand the adaptive repertoire of R. etli, because they include genes involved in small molecule metabolism, transport, and transcriptional regulation. Twenty-three putative sigma factors, numerous isozymes, and paralogous families attest to the metabolic redundancy and the genomic plasticity necessary to sustain the lifestyle of R. etli in symbiosis and in the soil.

Authors+Show Affiliations

Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, AP565-A Cuernavaca, Morelos, 62210, México. vgonzal@ccg.unam.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16505379

Citation

González, Víctor, et al. "The Partitioned Rhizobium Etli Genome: Genetic and Metabolic Redundancy in Seven Interacting Replicons." Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 10, 2006, pp. 3834-9.
González V, Santamaría RI, Bustos P, et al. The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons. Proc Natl Acad Sci USA. 2006;103(10):3834-9.
González, V., Santamaría, R. I., Bustos, P., Hernández-González, I., Medrano-Soto, A., Moreno-Hagelsieb, G., Janga, S. C., Ramírez, M. A., Jiménez-Jacinto, V., Collado-Vides, J., & Dávila, G. (2006). The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons. Proceedings of the National Academy of Sciences of the United States of America, 103(10), 3834-9.
González V, et al. The Partitioned Rhizobium Etli Genome: Genetic and Metabolic Redundancy in Seven Interacting Replicons. Proc Natl Acad Sci USA. 2006 Mar 7;103(10):3834-9. PubMed PMID: 16505379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons. AU - González,Víctor, AU - Santamaría,Rosa I, AU - Bustos,Patricia, AU - Hernández-González,Ismael, AU - Medrano-Soto,Arturo, AU - Moreno-Hagelsieb,Gabriel, AU - Janga,Sarath Chandra, AU - Ramírez,Miguel A, AU - Jiménez-Jacinto,Verónica, AU - Collado-Vides,Julio, AU - Dávila,Guillermo, Y1 - 2006/02/27/ PY - 2006/3/1/pubmed PY - 2006/4/18/medline PY - 2006/3/1/entrez SP - 3834 EP - 9 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 103 IS - 10 N2 - We report the complete 6,530,228-bp genome sequence of the symbiotic nitrogen fixing bacterium Rhizobium etli. Six large plasmids comprise one-third of the total genome size. The chromosome encodes most functions necessary for cell growth, whereas few essential genes or complete metabolic pathways are located in plasmids. Chromosomal synteny is disrupted by genes related to insertion sequences, phages, plasmids, and cell-surface components. Plasmids do not show synteny, and their orthologs are mostly shared by accessory replicons of species with multipartite genomes. Some nodulation genes are predicted to be functionally related with chromosomal loci encoding for the external envelope of the bacterium. Several pieces of evidence suggest an exogenous origin for the symbiotic plasmid (p42d) and p42a. Additional putative horizontal gene transfer events might have contributed to expand the adaptive repertoire of R. etli, because they include genes involved in small molecule metabolism, transport, and transcriptional regulation. Twenty-three putative sigma factors, numerous isozymes, and paralogous families attest to the metabolic redundancy and the genomic plasticity necessary to sustain the lifestyle of R. etli in symbiosis and in the soil. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/16505379/The_partitioned_Rhizobium_etli_genome:_genetic_and_metabolic_redundancy_in_seven_interacting_replicons_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16505379 DB - PRIME DP - Unbound Medicine ER -