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Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response.
Sex Transm Dis. 2006 Mar; 33(3):143-8.ST

Abstract

OBJECTIVES

To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection.

STUDY DESIGN

Cases of syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis.

RESULTS

Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm, P = 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm and -0.261 RNA log10 copies/ml, P = 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same.

CONCLUSION

Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis.

Authors+Show Affiliations

Clinical Research Unit, Hvidovre University Hospital, Copenhagen, Denmark. kristian.kofoed@hh.hosp.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16505739

Citation

Kofoed, Kristian, et al. "Syphilis and Human Immunodeficiency Virus (HIV)-1 Coinfection: Influence On CD4 T-cell Count, HIV-1 Viral Load, and Treatment Response." Sexually Transmitted Diseases, vol. 33, no. 3, 2006, pp. 143-8.
Kofoed K, Gerstoft J, Mathiesen LR, et al. Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response. Sex Transm Dis. 2006;33(3):143-8.
Kofoed, K., Gerstoft, J., Mathiesen, L. R., & Benfield, T. (2006). Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response. Sexually Transmitted Diseases, 33(3), 143-8.
Kofoed K, et al. Syphilis and Human Immunodeficiency Virus (HIV)-1 Coinfection: Influence On CD4 T-cell Count, HIV-1 Viral Load, and Treatment Response. Sex Transm Dis. 2006;33(3):143-8. PubMed PMID: 16505739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response. AU - Kofoed,Kristian, AU - Gerstoft,Jan, AU - Mathiesen,Lars R, AU - Benfield,Thomas, PY - 2006/3/1/pubmed PY - 2006/4/28/medline PY - 2006/3/1/entrez SP - 143 EP - 8 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 33 IS - 3 N2 - OBJECTIVES: To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection. STUDY DESIGN: Cases of syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis. RESULTS: Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm, P = 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm and -0.261 RNA log10 copies/ml, P = 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same. CONCLUSION: Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis. SN - 0148-5717 UR - https://www.unboundmedicine.com/medline/citation/16505739/Syphilis_and_human_immunodeficiency_virus__HIV__1_coinfection:_influence_on_CD4_T_cell_count_HIV_1_viral_load_and_treatment_response_ L2 - https://doi.org/10.1097/01.olq.0000187262.56820.c0 DB - PRIME DP - Unbound Medicine ER -