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The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease.
Pediatr Radiol. 2006 May; 36(5):415-20.PR

Abstract

BACKGROUND

Loss of bone mass is a known complication of chronic inflammatory bowel disease (IBD) in children. The gold standard in the evaluation of bone mineral density (BMD) is dual energy X-ray absorptiometry (DXA).

OBJECTIVE

In this preliminary study we evaluated digital X-ray radiogrammetry (DXR) which estimates BMD (DXR-BMD) from hand radiographs in children with IBD.

MATERIALS AND METHODS

A total of 26 children with IBD (10 girls, 16 boys; age range 10-18 years) underwent DXR for the calculation of DXR-BMD and metacarpal index (DXR-MCI) using the Pronosco X-posure system. The results were compared with a local reference database and correlated with the results of DXA.

RESULTS

DXR-BMD was 0.36-0.56 g/cm(2) (median 0.46 g/cm(2)) in Crohn disease patients and 0.38-0.63 g/cm(2) (median 0.48 g/cm(2)) in ulcerative colitis patients. DXR-MCI was 0.29-0.49 in Crohn disease patients and 0.28-0.53 in ulcerative colitis patients. The Z-scores were reduced to <-1 SD in five Crohn disease patients and in six ulcerative colitis patients. The coefficients (r) for the correlations between DXR-BMD and DXA-BMD were 0.78 for the lumbar spine and 0.61 for the proximal femur (P<0.01), and between DXR-MCI and DXA-BMD were 0.78 for the lumbar spine and 0.51 for the proximal femur (P<0.01).

CONCLUSIONS

DXR seems to be able to estimate cortical osteopenia in children with chronic IBD. The DXR results showed a positive correlation with DXA results.

Authors+Show Affiliations

Department of Pediatric Radiology, Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Bachstrasse 18, 07740, Jena, Germany. hans-joachim.mentzel@med.uni-jena.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

16506029

Citation

Mentzel, Hans-Joachim, et al. "The Potential of Digital X-ray Radiogrammetry (DXR) in the Assessment of Osteopenia in Children With Chronic Inflammatory Bowel Disease." Pediatric Radiology, vol. 36, no. 5, 2006, pp. 415-20.
Mentzel HJ, Blume J, Boettcher J, et al. The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease. Pediatr Radiol. 2006;36(5):415-20.
Mentzel, H. J., Blume, J., Boettcher, J., Lehmann, G., Tuchscherer, D., Pfeil, A., Kramer, A., Malich, A., Kauf, E., Hein, G., & Kaiser, W. A. (2006). The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease. Pediatric Radiology, 36(5), 415-20.
Mentzel HJ, et al. The Potential of Digital X-ray Radiogrammetry (DXR) in the Assessment of Osteopenia in Children With Chronic Inflammatory Bowel Disease. Pediatr Radiol. 2006;36(5):415-20. PubMed PMID: 16506029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease. AU - Mentzel,Hans-Joachim, AU - Blume,Joerg, AU - Boettcher,Joachim, AU - Lehmann,Gabriele, AU - Tuchscherer,Diana, AU - Pfeil,Alexander, AU - Kramer,Anika, AU - Malich,Ansgar, AU - Kauf,Eberhard, AU - Hein,Gert, AU - Kaiser,Werner A, Y1 - 2006/02/28/ PY - 2005/10/25/received PY - 2005/12/04/accepted PY - 2005/11/15/revised PY - 2006/3/1/pubmed PY - 2007/5/12/medline PY - 2006/3/1/entrez SP - 415 EP - 20 JF - Pediatric radiology JO - Pediatr Radiol VL - 36 IS - 5 N2 - BACKGROUND: Loss of bone mass is a known complication of chronic inflammatory bowel disease (IBD) in children. The gold standard in the evaluation of bone mineral density (BMD) is dual energy X-ray absorptiometry (DXA). OBJECTIVE: In this preliminary study we evaluated digital X-ray radiogrammetry (DXR) which estimates BMD (DXR-BMD) from hand radiographs in children with IBD. MATERIALS AND METHODS: A total of 26 children with IBD (10 girls, 16 boys; age range 10-18 years) underwent DXR for the calculation of DXR-BMD and metacarpal index (DXR-MCI) using the Pronosco X-posure system. The results were compared with a local reference database and correlated with the results of DXA. RESULTS: DXR-BMD was 0.36-0.56 g/cm(2) (median 0.46 g/cm(2)) in Crohn disease patients and 0.38-0.63 g/cm(2) (median 0.48 g/cm(2)) in ulcerative colitis patients. DXR-MCI was 0.29-0.49 in Crohn disease patients and 0.28-0.53 in ulcerative colitis patients. The Z-scores were reduced to <-1 SD in five Crohn disease patients and in six ulcerative colitis patients. The coefficients (r) for the correlations between DXR-BMD and DXA-BMD were 0.78 for the lumbar spine and 0.61 for the proximal femur (P<0.01), and between DXR-MCI and DXA-BMD were 0.78 for the lumbar spine and 0.51 for the proximal femur (P<0.01). CONCLUSIONS: DXR seems to be able to estimate cortical osteopenia in children with chronic IBD. The DXR results showed a positive correlation with DXA results. SN - 0301-0449 UR - https://www.unboundmedicine.com/medline/citation/16506029/The_potential_of_digital_X_ray_radiogrammetry__DXR__in_the_assessment_of_osteopenia_in_children_with_chronic_inflammatory_bowel_disease_ L2 - https://dx.doi.org/10.1007/s00247-005-0093-y DB - PRIME DP - Unbound Medicine ER -