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Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status.
Diabetes Metab Res Rev. 2006 Nov-Dec; 22(6):444-54.DM

Abstract

BACKGROUND

Diabetes is an inflammatory condition associated with iron abnormalities and increased oxidative damage. We aimed to investigate how diabetes affects the interrelationships between these pathogenic mechanisms.

METHODS

Glycaemic control, serum iron, proteins involved in iron homeostasis, global antioxidant capacity and levels of antioxidants and peroxidation products were measured in 39 type 1 and 67 type 2 diabetic patients and 100 control subjects.

RESULTS

Although serum iron was lower in diabetes, serum ferritin was elevated in type 2 diabetes (p = 0.02). This increase was not related to inflammation (C-reactive protein) but inversely correlated with soluble transferrin receptors (r = - 0.38, p = 0.002). Haptoglobin was higher in both type 1 and type 2 diabetes (p < 0.001) and haemopexin was higher in type 2 diabetes (p < 0.001). The relation between C-reactive protein and haemopexin was lost in type 2 diabetes (r = 0.15, p = 0.27 vs r = 0.63, p < 0.001 in type 1 diabetes and r = 0.36, p = 0.001 in controls). Haemopexin levels were independently determined by triacylglycerol (R(2) = 0.43) and the diabetic state (R(2) = 0.13). Regarding oxidative stress status, lower antioxidant concentrations were found for retinol and uric acid in type 1 diabetes, alpha-tocopherol and ascorbate in type 2 diabetes and protein thiols in both types. These decreases were partially explained by metabolic-, inflammatory- and iron alterations. An additional independent effect of the diabetic state on the oxidative stress status could be identified (R(2) = 0.5-0.14).

CONCLUSIONS

Circulating proteins, body iron stores, inflammation, oxidative stress and their interrelationships are abnormal in patients with diabetes and differ between type 1 and type 2 diabetes.

Authors+Show Affiliations

Laboratory of Endocrinology, Antwerp Metabolic Research Unit, University of Antwerp T4.37, Universiteitsplein 1, B-2610 Wilrijk-Antwerp, Belgium. ann.vancampenhout@ua.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16506275

Citation

Van Campenhout, Ann, et al. "Impact of Diabetes Mellitus On the Relationships Between Iron-, Inflammatory- and Oxidative Stress Status." Diabetes/metabolism Research and Reviews, vol. 22, no. 6, 2006, pp. 444-54.
Van Campenhout A, Van Campenhout C, Lagrou AR, et al. Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status. Diabetes Metab Res Rev. 2006;22(6):444-54.
Van Campenhout, A., Van Campenhout, C., Lagrou, A. R., Abrams, P., Moorkens, G., Van Gaal, L., & Manuel-y-Keenoy, B. (2006). Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status. Diabetes/metabolism Research and Reviews, 22(6), 444-54.
Van Campenhout A, et al. Impact of Diabetes Mellitus On the Relationships Between Iron-, Inflammatory- and Oxidative Stress Status. Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):444-54. PubMed PMID: 16506275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status. AU - Van Campenhout,Ann, AU - Van Campenhout,Christel, AU - Lagrou,Albert R, AU - Abrams,Pascale, AU - Moorkens,Greta, AU - Van Gaal,Luc, AU - Manuel-y-Keenoy,Begoña, PY - 2006/3/1/pubmed PY - 2006/12/19/medline PY - 2006/3/1/entrez SP - 444 EP - 54 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 22 IS - 6 N2 - BACKGROUND: Diabetes is an inflammatory condition associated with iron abnormalities and increased oxidative damage. We aimed to investigate how diabetes affects the interrelationships between these pathogenic mechanisms. METHODS: Glycaemic control, serum iron, proteins involved in iron homeostasis, global antioxidant capacity and levels of antioxidants and peroxidation products were measured in 39 type 1 and 67 type 2 diabetic patients and 100 control subjects. RESULTS: Although serum iron was lower in diabetes, serum ferritin was elevated in type 2 diabetes (p = 0.02). This increase was not related to inflammation (C-reactive protein) but inversely correlated with soluble transferrin receptors (r = - 0.38, p = 0.002). Haptoglobin was higher in both type 1 and type 2 diabetes (p < 0.001) and haemopexin was higher in type 2 diabetes (p < 0.001). The relation between C-reactive protein and haemopexin was lost in type 2 diabetes (r = 0.15, p = 0.27 vs r = 0.63, p < 0.001 in type 1 diabetes and r = 0.36, p = 0.001 in controls). Haemopexin levels were independently determined by triacylglycerol (R(2) = 0.43) and the diabetic state (R(2) = 0.13). Regarding oxidative stress status, lower antioxidant concentrations were found for retinol and uric acid in type 1 diabetes, alpha-tocopherol and ascorbate in type 2 diabetes and protein thiols in both types. These decreases were partially explained by metabolic-, inflammatory- and iron alterations. An additional independent effect of the diabetic state on the oxidative stress status could be identified (R(2) = 0.5-0.14). CONCLUSIONS: Circulating proteins, body iron stores, inflammation, oxidative stress and their interrelationships are abnormal in patients with diabetes and differ between type 1 and type 2 diabetes. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/16506275/Impact_of_diabetes_mellitus_on_the_relationships_between_iron__inflammatory__and_oxidative_stress_status_ L2 - https://doi.org/10.1002/dmrr.635 DB - PRIME DP - Unbound Medicine ER -