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Antifungal activity of thiophenes from Echinops ritro.
J Agric Food Chem. 2006 Mar 08; 54(5):1651-5.JA

Abstract

Extracts from 30 plants of the Greek flora were evaluated for their antifungal activity using direct bioautography assays with three Colletotrichum species. Among the bioactive extracts, the dichloromethane extract of the radix of Echinops ritro (Asteraceae) was the most potent. Bioassay-guided fractionation of this extract led to the isolation of eight thiophenes. Antifungal activities of isolated compounds together with a previously isolated thiophene from Echinops transiliensis were first evaluated by bioautography and subsequently evaluated in greater detail using a broth microdilution assay against plant pathogens Colletotrichum acutatum, Colletotrichum fragariae, Colletotrichum gloeosporioides, Botrytis cinerea, Fusarium oxysporum, Phomopsis viticola, and Phomopsis obscurans. 5'-(3-Buten-1-ynyl)-2,2'-bithiophen (1), alpha-terthienyl (2), and 2-[pent-1,3-diynyl]-5-[4-hydroxybut-1-ynyl]thiophene (5) at 3 and 30 microM were active against all three Colletotrichum species, F. oxysporum, P. viticola, and P. obscurans.

Authors+Show Affiliations

Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, P.O.Box 8048, University of Mississippi, University, Mississippi 38677, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16506815

Citation

Fokialakis, Nikolas, et al. "Antifungal Activity of Thiophenes From Echinops Ritro." Journal of Agricultural and Food Chemistry, vol. 54, no. 5, 2006, pp. 1651-5.
Fokialakis N, Cantrell CL, Duke SO, et al. Antifungal activity of thiophenes from Echinops ritro. J Agric Food Chem. 2006;54(5):1651-5.
Fokialakis, N., Cantrell, C. L., Duke, S. O., Skaltsounis, A. L., & Wedge, D. E. (2006). Antifungal activity of thiophenes from Echinops ritro. Journal of Agricultural and Food Chemistry, 54(5), 1651-5.
Fokialakis N, et al. Antifungal Activity of Thiophenes From Echinops Ritro. J Agric Food Chem. 2006 Mar 8;54(5):1651-5. PubMed PMID: 16506815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of thiophenes from Echinops ritro. AU - Fokialakis,Nikolas, AU - Cantrell,Charles L, AU - Duke,Stephen O, AU - Skaltsounis,Alexios L, AU - Wedge,David E, PY - 2006/3/2/pubmed PY - 2006/5/9/medline PY - 2006/3/2/entrez SP - 1651 EP - 5 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 54 IS - 5 N2 - Extracts from 30 plants of the Greek flora were evaluated for their antifungal activity using direct bioautography assays with three Colletotrichum species. Among the bioactive extracts, the dichloromethane extract of the radix of Echinops ritro (Asteraceae) was the most potent. Bioassay-guided fractionation of this extract led to the isolation of eight thiophenes. Antifungal activities of isolated compounds together with a previously isolated thiophene from Echinops transiliensis were first evaluated by bioautography and subsequently evaluated in greater detail using a broth microdilution assay against plant pathogens Colletotrichum acutatum, Colletotrichum fragariae, Colletotrichum gloeosporioides, Botrytis cinerea, Fusarium oxysporum, Phomopsis viticola, and Phomopsis obscurans. 5'-(3-Buten-1-ynyl)-2,2'-bithiophen (1), alpha-terthienyl (2), and 2-[pent-1,3-diynyl]-5-[4-hydroxybut-1-ynyl]thiophene (5) at 3 and 30 microM were active against all three Colletotrichum species, F. oxysporum, P. viticola, and P. obscurans. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16506815/Antifungal_activity_of_thiophenes_from_Echinops_ritro_ L2 - https://dx.doi.org/10.1021/jf052702j DB - PRIME DP - Unbound Medicine ER -