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Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004.
Trans R Soc Trop Med Hyg. 2006 Sep; 100(9):855-62.TR

Abstract

Periodic outbreaks of dengue have emerged in Indonesia since 1968, with the severity of resulting disease increasing in subsequent years. In early 2004, a purported dengue outbreak erupted across the archipelago, with over 50,000 cases and 603 deaths reported. To confirm the disease aetiology and to provide an epidemiological framework of this epidemic, an investigation was conducted in ten hospitals within the capital city of Jakarta. Clinical and laboratory findings were determined from a cohort of 272 hospitalised patients. Exposure to dengue virus was determined in 180 (66.2%) patients. When clinically assessed, 100 (55.6%) of the 180 patients were classified as having dengue fever (DF), 31 (17.2%) as DF with haemorrhagic manifestations and 49 (27.2%) as dengue haemorrhagic fever (DHF). Evidence from haemagglutination inhibition assays suggested that 33/40 (82.5%) of those with DHF from which laboratory evidence was available suffered from a secondary dengue infection. All four dengue viruses were identified upon viral isolation, with DEN-3 being the most predominant serotype recovered, followed by DEN-4, DEN-2 and DEN-1. In summary, the 2004 outbreak of dengue in Jakarta, Indonesia, was characterised by the circulation of multiple virus serotypes and resulted in a relatively high percentage of a representative population of hospitalised patients developing DHF.

Authors+Show Affiliations

National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16507313

Citation

Suwandono, Agus, et al. "Four Dengue Virus Serotypes Found Circulating During an Outbreak of Dengue Fever and Dengue Haemorrhagic Fever in Jakarta, Indonesia, During 2004." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 9, 2006, pp. 855-62.
Suwandono A, Kosasih H, Nurhayati , et al. Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004. Trans R Soc Trop Med Hyg. 2006;100(9):855-62.
Suwandono, A., Kosasih, H., Nurhayati, ., Kusriastuti, R., Harun, S., Ma'roef, C., Wuryadi, S., Herianto, B., Yuwono, D., Porter, K. R., Beckett, C. G., & Blair, P. J. (2006). Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(9), 855-62.
Suwandono A, et al. Four Dengue Virus Serotypes Found Circulating During an Outbreak of Dengue Fever and Dengue Haemorrhagic Fever in Jakarta, Indonesia, During 2004. Trans R Soc Trop Med Hyg. 2006;100(9):855-62. PubMed PMID: 16507313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004. AU - Suwandono,Agus, AU - Kosasih,Herman, AU - Nurhayati,, AU - Kusriastuti,Rita, AU - Harun,Syahrial, AU - Ma'roef,Chairin, AU - Wuryadi,Suharyono, AU - Herianto,Bambang, AU - Yuwono,Djoko, AU - Porter,Kevin R, AU - Beckett,Charmagne G, AU - Blair,Patrick J, Y1 - 2006/02/28/ PY - 2005/07/07/received PY - 2005/11/04/revised PY - 2005/11/08/accepted PY - 2006/3/2/pubmed PY - 2006/12/12/medline PY - 2006/3/2/entrez SP - 855 EP - 62 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 100 IS - 9 N2 - Periodic outbreaks of dengue have emerged in Indonesia since 1968, with the severity of resulting disease increasing in subsequent years. In early 2004, a purported dengue outbreak erupted across the archipelago, with over 50,000 cases and 603 deaths reported. To confirm the disease aetiology and to provide an epidemiological framework of this epidemic, an investigation was conducted in ten hospitals within the capital city of Jakarta. Clinical and laboratory findings were determined from a cohort of 272 hospitalised patients. Exposure to dengue virus was determined in 180 (66.2%) patients. When clinically assessed, 100 (55.6%) of the 180 patients were classified as having dengue fever (DF), 31 (17.2%) as DF with haemorrhagic manifestations and 49 (27.2%) as dengue haemorrhagic fever (DHF). Evidence from haemagglutination inhibition assays suggested that 33/40 (82.5%) of those with DHF from which laboratory evidence was available suffered from a secondary dengue infection. All four dengue viruses were identified upon viral isolation, with DEN-3 being the most predominant serotype recovered, followed by DEN-4, DEN-2 and DEN-1. In summary, the 2004 outbreak of dengue in Jakarta, Indonesia, was characterised by the circulation of multiple virus serotypes and resulted in a relatively high percentage of a representative population of hospitalised patients developing DHF. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/16507313/Four_dengue_virus_serotypes_found_circulating_during_an_outbreak_of_dengue_fever_and_dengue_haemorrhagic_fever_in_Jakarta_Indonesia_during_2004_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(06)00004-6 DB - PRIME DP - Unbound Medicine ER -