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Is a nappy change stressful to neonates?
Early Hum Dev. 2006 Oct; 82(10):669-76.EH

Abstract

OBJECTIVES

Infants in neonatal intensive care (NICU infants) are often cared for in a stressful environment that includes potentially painful or stressful interventions. The aim was to investigate whether NICU infants have different pattern of stress and pain responses than healthy newborns when challenged by a non-painful everyday care routine.

METHODS

NICU infants born at 23-38 weeks gestation (n=39) were compared to healthy full-term newborns (n=30). Cortisol concentrations in saliva were determined before and 30 min after a standardised nappy change. The premature infant pain profile (PIPP) and the neonatal infant pain scale (NIPS) were evaluated before, during, directly after, 3 min after, and 30 min after the nappy change. The investigation was performed on two different occasions, first between postnatal days 2-7 and then between postnatal days 10-18.

RESULTS

NICU infants had higher median baseline salivary cortisol levels compared to full-term newborns on both occasions (17.1 nmol/L vs. 6.2 nmol/L p<0.01 and 8.5 nmol/L vs. 2.4 nmol/L p<0.01, respectively). Salivary cortisol decreased in response to the second nappy change in NICU infants (p=0.01). NICU infants had higher PIPP scores during both nappy changes (p<0.001 for both occasions) and more sustained increases in PIPP and NIPS up to 30 min after the nappy changes compared to full-term newborns.

CONCLUSIONS

NICU infants have higher baseline salivary cortisol than healthy full-term newborns. There is a change in baseline cortisol by age in both groups. Full-term infants as well as NICU infants show an increased pain response to a standardised nappy change.

Authors+Show Affiliations

Department of Molecular and Clinical Medicine/Division of Paediatrics, Linköping University Hospital, SE-581 85 Linköping, Sweden. evalotte.morelius@lio.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16507341

Citation

Mörelius, Evalotte, et al. "Is a Nappy Change Stressful to Neonates?" Early Human Development, vol. 82, no. 10, 2006, pp. 669-76.
Mörelius E, Hellström-Westas L, Carlén C, et al. Is a nappy change stressful to neonates? Early Hum Dev. 2006;82(10):669-76.
Mörelius, E., Hellström-Westas, L., Carlén, C., Norman, E., & Nelson, N. (2006). Is a nappy change stressful to neonates? Early Human Development, 82(10), 669-76.
Mörelius E, et al. Is a Nappy Change Stressful to Neonates. Early Hum Dev. 2006;82(10):669-76. PubMed PMID: 16507341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is a nappy change stressful to neonates? AU - Mörelius,Evalotte, AU - Hellström-Westas,Lena, AU - Carlén,Catarina, AU - Norman,Elisabeth, AU - Nelson,Nina, Y1 - 2006/02/28/ PY - 2005/08/09/received PY - 2005/12/15/revised PY - 2005/12/22/accepted PY - 2006/3/2/pubmed PY - 2006/12/9/medline PY - 2006/3/2/entrez SP - 669 EP - 76 JF - Early human development JO - Early Hum Dev VL - 82 IS - 10 N2 - OBJECTIVES: Infants in neonatal intensive care (NICU infants) are often cared for in a stressful environment that includes potentially painful or stressful interventions. The aim was to investigate whether NICU infants have different pattern of stress and pain responses than healthy newborns when challenged by a non-painful everyday care routine. METHODS: NICU infants born at 23-38 weeks gestation (n=39) were compared to healthy full-term newborns (n=30). Cortisol concentrations in saliva were determined before and 30 min after a standardised nappy change. The premature infant pain profile (PIPP) and the neonatal infant pain scale (NIPS) were evaluated before, during, directly after, 3 min after, and 30 min after the nappy change. The investigation was performed on two different occasions, first between postnatal days 2-7 and then between postnatal days 10-18. RESULTS: NICU infants had higher median baseline salivary cortisol levels compared to full-term newborns on both occasions (17.1 nmol/L vs. 6.2 nmol/L p<0.01 and 8.5 nmol/L vs. 2.4 nmol/L p<0.01, respectively). Salivary cortisol decreased in response to the second nappy change in NICU infants (p=0.01). NICU infants had higher PIPP scores during both nappy changes (p<0.001 for both occasions) and more sustained increases in PIPP and NIPS up to 30 min after the nappy changes compared to full-term newborns. CONCLUSIONS: NICU infants have higher baseline salivary cortisol than healthy full-term newborns. There is a change in baseline cortisol by age in both groups. Full-term infants as well as NICU infants show an increased pain response to a standardised nappy change. SN - 0378-3782 UR - https://www.unboundmedicine.com/medline/citation/16507341/Is_a_nappy_change_stressful_to_neonates L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-3782(06)00039-9 DB - PRIME DP - Unbound Medicine ER -