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A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years.
Clin Ther. 2005 Dec; 27(12):1950-60.CT

Abstract

OBJECTIVE

This analysis of the results of 7 trials compared the taste and smell acceptability scores of cefdinir oral suspension and 4 other pediatric antibiotic oral suspensions--amoxicillin/clavulanate potassium, cefprozil, azithromycin, or generic amoxicillin--using a visual smile-face scale.

METHODS

Data from 7 randomized, single-blind, cross-over trials were pooled and analyzed. In each study, children aged 4 to 8 years were asked to taste and smell 2 different antibiotic suspensions and assign preference using a visual smile-face scale. Ratings were converted to a numeric score ranging from 5 (really good) to 1 (really bad).

RESULTS

A total of 1011 healthy subjects were randomly assigned to 1 of 2 treatment-order groups; 965 were evaluable for the taste and smell analyses. Baseline demographics of evaluable subjects were similar among test groups. Approximately even proportions of participants were female or male (50.1 % vs 49.9%), most (84.1%) were white, and slightly more participants were aged 7 or 8 years rather than younger (age 4 years, 16.0%; age 5 years, 17.4%; age 6 years, 18.7%; age 7 years, 23.2%; age 8 years, 24.8%). Of the 965 children who tasted both antibiotic suspensions and determined their preference, 798 (82.7%) rated the taste of cefdinir as really good or good (the highest possible ratings); 712 (73.8%) assigned the same ratings to amoxicillin/clavulanate potassium, cefprozil, azithromycin, or generic amoxicillin (P < or = 0.001). With regard to smell, 671 (69.5%) rated the smell of cefdinir as really good or good; 636 (65.9%) assigned these same ratings to the comparator agents (P = NS).

CONCLUSION

In this pooled analysis of data from 7 randomized, single-blind, crossover trials, children between the ages of 4 and 8 years preferred the taste of cefdinir oral suspension to that of other pediatric antibiotic suspensions. Based on smile-face scores, subjects found the smell of cefdinir oral suspension to be at least as good as that of the comparators.

Authors+Show Affiliations

Abbott Laboratories, Abbott Park, IL 60064, USA. cynthia.holas@abbott.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16507381

Citation

Holas, Cynthia, et al. "A Pooled Analysis of Seven Randomized Crossover Studies of the Palatability of Cefdinir Oral Suspension Versus Amoxicillin/clavulanate Potassium, Cefprozil, Azithromycin, and Amoxicillin in Children Aged 4 to 8 Years." Clinical Therapeutics, vol. 27, no. 12, 2005, pp. 1950-60.
Holas C, Chiu YL, Notario G, et al. A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years. Clin Ther. 2005;27(12):1950-60.
Holas, C., Chiu, Y. L., Notario, G., & Kapral, D. (2005). A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years. Clinical Therapeutics, 27(12), 1950-60.
Holas C, et al. A Pooled Analysis of Seven Randomized Crossover Studies of the Palatability of Cefdinir Oral Suspension Versus Amoxicillin/clavulanate Potassium, Cefprozil, Azithromycin, and Amoxicillin in Children Aged 4 to 8 Years. Clin Ther. 2005;27(12):1950-60. PubMed PMID: 16507381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years. AU - Holas,Cynthia, AU - Chiu,Yi-Lin, AU - Notario,Gerard, AU - Kapral,Dolores, PY - 2005/11/04/accepted PY - 2006/3/2/pubmed PY - 2006/4/12/medline PY - 2006/3/2/entrez SP - 1950 EP - 60 JF - Clinical therapeutics JO - Clin Ther VL - 27 IS - 12 N2 - OBJECTIVE: This analysis of the results of 7 trials compared the taste and smell acceptability scores of cefdinir oral suspension and 4 other pediatric antibiotic oral suspensions--amoxicillin/clavulanate potassium, cefprozil, azithromycin, or generic amoxicillin--using a visual smile-face scale. METHODS: Data from 7 randomized, single-blind, cross-over trials were pooled and analyzed. In each study, children aged 4 to 8 years were asked to taste and smell 2 different antibiotic suspensions and assign preference using a visual smile-face scale. Ratings were converted to a numeric score ranging from 5 (really good) to 1 (really bad). RESULTS: A total of 1011 healthy subjects were randomly assigned to 1 of 2 treatment-order groups; 965 were evaluable for the taste and smell analyses. Baseline demographics of evaluable subjects were similar among test groups. Approximately even proportions of participants were female or male (50.1 % vs 49.9%), most (84.1%) were white, and slightly more participants were aged 7 or 8 years rather than younger (age 4 years, 16.0%; age 5 years, 17.4%; age 6 years, 18.7%; age 7 years, 23.2%; age 8 years, 24.8%). Of the 965 children who tasted both antibiotic suspensions and determined their preference, 798 (82.7%) rated the taste of cefdinir as really good or good (the highest possible ratings); 712 (73.8%) assigned the same ratings to amoxicillin/clavulanate potassium, cefprozil, azithromycin, or generic amoxicillin (P < or = 0.001). With regard to smell, 671 (69.5%) rated the smell of cefdinir as really good or good; 636 (65.9%) assigned these same ratings to the comparator agents (P = NS). CONCLUSION: In this pooled analysis of data from 7 randomized, single-blind, crossover trials, children between the ages of 4 and 8 years preferred the taste of cefdinir oral suspension to that of other pediatric antibiotic suspensions. Based on smile-face scores, subjects found the smell of cefdinir oral suspension to be at least as good as that of the comparators. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/16507381/A_pooled_analysis_of_seven_randomized_crossover_studies_of_the_palatability_of_cefdinir_oral_suspension_versus_amoxicillin/clavulanate_potassium_cefprozil_azithromycin_and_amoxicillin_in_children_aged_4_to_8_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-2918(05)00296-1 DB - PRIME DP - Unbound Medicine ER -