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Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome.
J Clin Endocrinol Metab. 2006 May; 91(5):1876-81.JC

Abstract

CONTEXT

Decreased fasting ghrelin levels and decreased ghrelin suppression in overweight children have been reported to be associated with insulin resistance. However, Prader-Willi syndrome (PWS) is associated with increased total ghrelin levels and relative hypoinsulinemia.

OBJECTIVE

The objective of the study was to analyze changes in acylated ghrelin (AG) and des-acylated ghrelin (DAG) levels after glucose loading and characterize correlations between insulin sensitivity and ghrelin suppression.

DESIGN

Plasma glucose, insulin, AG, and DAG levels were measured in PWS children (n = 11) and normal obese controls (n = 10) during oral glucose tolerance testing.

SETTING

All subjects were admitted to the Samsung Medical Center.

INTERVENTIONS

Oral glucose tolerance testing was performed in all subjects after an overnight fast.

MAIN OUTCOME MEASURES

Plasma levels of the hormones AG, DAG, and insulin, and those of glucose at 0, 30, 60, 90, and 120 min after glucose challenge were measured, and whole-body insulin sensitivity index (WBISI) values were calculated.

RESULTS

AG levels fell markedly more from fasting levels in PWS children than normal healthy obese controls at 30, 60, and 90 min after glucose challenge, but no significant differences in DAG levels were observed at any time between PWS patients and controls. Fasting AG and DAG levels were found to correlate with WBISI in PWS, and absolute suppressions (Delta from baseline) in AG at 30 min after glucose challenge (nadir) were also correlated with WBISI in PWS (r = 0.64, P = 0.035).

CONCLUSIONS

Our results suggest that AG is sensitively suppressed by insulin and that this suppression correlated with insulin sensitivity in PWS children.

Authors+Show Affiliations

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Il-Won Dong, Gang-Nam Gu, Seoul 135-710, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16507634

Citation

Paik, Kyung Hoon, et al. "Suppression of Acylated Ghrelin During Oral Glucose Tolerance Test Is Correlated With Whole-body Insulin Sensitivity in Children With Prader-Willi Syndrome." The Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 5, 2006, pp. 1876-81.
Paik KH, Choe YH, Park WH, et al. Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome. J Clin Endocrinol Metab. 2006;91(5):1876-81.
Paik, K. H., Choe, Y. H., Park, W. H., Oh, Y. J., Kim, A. H., Chu, S. H., Kim, S. W., Kwon, E. K., Han, S. J., Shon, W. Y., & Jin, D. K. (2006). Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome. The Journal of Clinical Endocrinology and Metabolism, 91(5), 1876-81.
Paik KH, et al. Suppression of Acylated Ghrelin During Oral Glucose Tolerance Test Is Correlated With Whole-body Insulin Sensitivity in Children With Prader-Willi Syndrome. J Clin Endocrinol Metab. 2006;91(5):1876-81. PubMed PMID: 16507634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syndrome. AU - Paik,Kyung Hoon, AU - Choe,Yon Ho, AU - Park,Won Hah, AU - Oh,Yoo Joung, AU - Kim,An Hee, AU - Chu,Su Hyun, AU - Kim,Seon Woo, AU - Kwon,Eun Kyung, AU - Han,Sun Ju, AU - Shon,Woo Yun, AU - Jin,Dong-Kyu, Y1 - 2006/02/28/ PY - 2006/3/2/pubmed PY - 2006/6/8/medline PY - 2006/3/2/entrez SP - 1876 EP - 81 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 91 IS - 5 N2 - CONTEXT: Decreased fasting ghrelin levels and decreased ghrelin suppression in overweight children have been reported to be associated with insulin resistance. However, Prader-Willi syndrome (PWS) is associated with increased total ghrelin levels and relative hypoinsulinemia. OBJECTIVE: The objective of the study was to analyze changes in acylated ghrelin (AG) and des-acylated ghrelin (DAG) levels after glucose loading and characterize correlations between insulin sensitivity and ghrelin suppression. DESIGN: Plasma glucose, insulin, AG, and DAG levels were measured in PWS children (n = 11) and normal obese controls (n = 10) during oral glucose tolerance testing. SETTING: All subjects were admitted to the Samsung Medical Center. INTERVENTIONS: Oral glucose tolerance testing was performed in all subjects after an overnight fast. MAIN OUTCOME MEASURES: Plasma levels of the hormones AG, DAG, and insulin, and those of glucose at 0, 30, 60, 90, and 120 min after glucose challenge were measured, and whole-body insulin sensitivity index (WBISI) values were calculated. RESULTS: AG levels fell markedly more from fasting levels in PWS children than normal healthy obese controls at 30, 60, and 90 min after glucose challenge, but no significant differences in DAG levels were observed at any time between PWS patients and controls. Fasting AG and DAG levels were found to correlate with WBISI in PWS, and absolute suppressions (Delta from baseline) in AG at 30 min after glucose challenge (nadir) were also correlated with WBISI in PWS (r = 0.64, P = 0.035). CONCLUSIONS: Our results suggest that AG is sensitively suppressed by insulin and that this suppression correlated with insulin sensitivity in PWS children. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/16507634/Suppression_of_acylated_ghrelin_during_oral_glucose_tolerance_test_is_correlated_with_whole_body_insulin_sensitivity_in_children_with_Prader_Willi_syndrome_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2005-2168 DB - PRIME DP - Unbound Medicine ER -