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Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).

Abstract

BACKGROUND

Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort.

METHODS

A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided.

RESULTS

During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake.

CONCLUSION

Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain. cagonzalez@ico.scs.es

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    Journal of the National Cancer Institute 98:5 2006 Mar 01 pg 345-54

    MeSH

    Adenocarcinoma
    Adult
    Aged
    Cardia
    Case-Control Studies
    Confidence Intervals
    Esophageal Neoplasms
    Europe
    Feeding Behavior
    Female
    Follow-Up Studies
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Incidence
    Life Style
    Male
    Meat
    Middle Aged
    Odds Ratio
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Stomach Neoplasms
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16507831

    Citation

    González, Carlos A., et al. "Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Journal of the National Cancer Institute, vol. 98, no. 5, 2006, pp. 345-54.
    González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54.
    González, C. A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S., Palli, D., ... Riboli, E. (2006). Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). Journal of the National Cancer Institute, 98(5), pp. 345-54.
    González CA, et al. Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006 Mar 1;98(5):345-54. PubMed PMID: 16507831.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). AU - González,Carlos A, AU - Jakszyn,Paula, AU - Pera,Guillem, AU - Agudo,Antonio, AU - Bingham,Sheila, AU - Palli,Domenico, AU - Ferrari,Pietro, AU - Boeing,Heiner, AU - del Giudice,Giuseppe, AU - Plebani,Mario, AU - Carneiro,Fátima, AU - Nesi,Gabriella, AU - Berrino,Franco, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Berglund,Göran, AU - Simán,Henrik, AU - Nyrén,Olof, AU - Hallmans,Göran, AU - Martinez,Carmen, AU - Dorronsoro,Miren, AU - Barricarte,Aurelio, AU - Navarro,Carmen, AU - Quirós,José R, AU - Allen,Naomi, AU - Key,Timothy J, AU - Day,Nicholas E, AU - Linseisen,Jakob, AU - Nagel,Gabriele, AU - Bergmann,Manuela M, AU - Overvad,Kim, AU - Jensen,Majken K, AU - Tjonneland,Anne, AU - Olsen,Anja, AU - Bueno-de-Mesquita,H Bas, AU - Ocke,Marga, AU - Peeters,Petra H M, AU - Numans,Mattijs E, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Trichopoulou,Antonia, AU - Psaltopoulou,Theodora, AU - Roukos,Dimitrios, AU - Lund,Eiliv, AU - Hemon,Bertrand, AU - Kaaks,Rudolf, AU - Norat,Teresa, AU - Riboli,Elio, PY - 2006/3/2/pubmed PY - 2006/3/8/medline PY - 2006/3/2/entrez SP - 345 EP - 54 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 98 IS - 5 N2 - BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/16507831/Meat_intake_and_risk_of_stomach_and_esophageal_adenocarcinoma_within_the_European_Prospective_Investigation_Into_Cancer_and_Nutrition__EPIC__ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djj071 DB - PRIME DP - Unbound Medicine ER -