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Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).
J Natl Cancer Inst 2006; 98(5):345-54JNCI

Abstract

BACKGROUND

Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort.

METHODS

A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided.

RESULTS

During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake.

CONCLUSION

Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

Authors+Show Affiliations

Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain. cagonzalez@ico.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16507831

Citation

González, Carlos A., et al. "Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Journal of the National Cancer Institute, vol. 98, no. 5, 2006, pp. 345-54.
González CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(5):345-54.
González, C. A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S., Palli, D., ... Riboli, E. (2006). Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). Journal of the National Cancer Institute, 98(5), pp. 345-54.
González CA, et al. Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006 Mar 1;98(5):345-54. PubMed PMID: 16507831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). AU - González,Carlos A, AU - Jakszyn,Paula, AU - Pera,Guillem, AU - Agudo,Antonio, AU - Bingham,Sheila, AU - Palli,Domenico, AU - Ferrari,Pietro, AU - Boeing,Heiner, AU - del Giudice,Giuseppe, AU - Plebani,Mario, AU - Carneiro,Fátima, AU - Nesi,Gabriella, AU - Berrino,Franco, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Berglund,Göran, AU - Simán,Henrik, AU - Nyrén,Olof, AU - Hallmans,Göran, AU - Martinez,Carmen, AU - Dorronsoro,Miren, AU - Barricarte,Aurelio, AU - Navarro,Carmen, AU - Quirós,José R, AU - Allen,Naomi, AU - Key,Timothy J, AU - Day,Nicholas E, AU - Linseisen,Jakob, AU - Nagel,Gabriele, AU - Bergmann,Manuela M, AU - Overvad,Kim, AU - Jensen,Majken K, AU - Tjonneland,Anne, AU - Olsen,Anja, AU - Bueno-de-Mesquita,H Bas, AU - Ocke,Marga, AU - Peeters,Petra H M, AU - Numans,Mattijs E, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Trichopoulou,Antonia, AU - Psaltopoulou,Theodora, AU - Roukos,Dimitrios, AU - Lund,Eiliv, AU - Hemon,Bertrand, AU - Kaaks,Rudolf, AU - Norat,Teresa, AU - Riboli,Elio, PY - 2006/3/2/pubmed PY - 2006/3/8/medline PY - 2006/3/2/entrez SP - 345 EP - 54 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 98 IS - 5 N2 - BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/16507831/Meat_intake_and_risk_of_stomach_and_esophageal_adenocarcinoma_within_the_European_Prospective_Investigation_Into_Cancer_and_Nutrition__EPIC__ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djj071 DB - PRIME DP - Unbound Medicine ER -