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Action of Dracocephalum argunense on mast cell-mediated allergy model.
Biol Pharm Bull. 2006 Mar; 29(3):494-8.BP

Abstract

The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells starts the process of degranulation resulting in releasing of mediators, such as histamine. In this report, we investigated the effect of aqueous extract of Dracocephalum argunense Fisch. (Labiatae) (DAAE) on the mast cell-mediated allergic response and studied its possible mechanisms of action, focusing on the histamine release and pro-inflammatory cytokine secretion in mast cells. DAAE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. In addition, DAAE attenuated IgE-mediated skin allergic reaction. DAAE dose-dependently reduced IgE-induced histamine release from mast cells. The level of cAMP was transiently increased by treatment of DAAE. DAAE specifically blocked the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced p38 mitogen-activated protein kinase (MAPK) activation. DAAE decreased the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 in mast cells. Our findings provide evidence that DAAE inhibits mast cell derived allergic reactions, and involvement of cAMP for histamine release and p38 MAPK for pro-inflammatory cytokine secretion in these effects.

Authors+Show Affiliations

Department of Pharmacology, Kyungpook National University Medical School, Daegu, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16508152

Citation

Kim, Sang-Hyun, et al. "Action of Dracocephalum Argunense On Mast Cell-mediated Allergy Model." Biological & Pharmaceutical Bulletin, vol. 29, no. 3, 2006, pp. 494-8.
Kim SH, Kim SH, Kim SH, et al. Action of Dracocephalum argunense on mast cell-mediated allergy model. Biol Pharm Bull. 2006;29(3):494-8.
Kim, S. H., Kim, S. H., Kim, S. H., Moon, J. Y., Park, W. H., Kim, C. H., & Shin, T. Y. (2006). Action of Dracocephalum argunense on mast cell-mediated allergy model. Biological & Pharmaceutical Bulletin, 29(3), 494-8.
Kim SH, et al. Action of Dracocephalum Argunense On Mast Cell-mediated Allergy Model. Biol Pharm Bull. 2006;29(3):494-8. PubMed PMID: 16508152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Action of Dracocephalum argunense on mast cell-mediated allergy model. AU - Kim,Sang-Hyun, AU - Kim,Sug-Hyun, AU - Kim,Sung-Hwa, AU - Moon,Jin-Young, AU - Park,Won-Hwan, AU - Kim,Cheorl-Ho, AU - Shin,Tae-Yong, PY - 2006/3/2/pubmed PY - 2006/5/18/medline PY - 2006/3/2/entrez SP - 494 EP - 8 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 29 IS - 3 N2 - The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells starts the process of degranulation resulting in releasing of mediators, such as histamine. In this report, we investigated the effect of aqueous extract of Dracocephalum argunense Fisch. (Labiatae) (DAAE) on the mast cell-mediated allergic response and studied its possible mechanisms of action, focusing on the histamine release and pro-inflammatory cytokine secretion in mast cells. DAAE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. In addition, DAAE attenuated IgE-mediated skin allergic reaction. DAAE dose-dependently reduced IgE-induced histamine release from mast cells. The level of cAMP was transiently increased by treatment of DAAE. DAAE specifically blocked the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced p38 mitogen-activated protein kinase (MAPK) activation. DAAE decreased the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 in mast cells. Our findings provide evidence that DAAE inhibits mast cell derived allergic reactions, and involvement of cAMP for histamine release and p38 MAPK for pro-inflammatory cytokine secretion in these effects. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/16508152/Action_of_Dracocephalum_argunense_on_mast_cell_mediated_allergy_model_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/29.494?from=PubMed DB - PRIME DP - Unbound Medicine ER -