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[The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma].

Abstract

In order to clarify whether repirinast, an inhibitor of chemical mediator release, could influence the pharmacokinetics of theophylline, a loading test using intravenous injection of aminophylline was performed in 10 subjects with bronchial asthma before and after treatment with 300 mg/day of repirinast. There was no significant difference in theophylline half-life before treatment (7.25 +/- 2.43 hr) and after treatment (7.82 +/- 3.35 hr). There was no significant difference in theophylline clearance before treatment (0.047 +/- 0.018 L/kg/hr) and after treatment (0.047 +/- 0.020 L/kg/hr). These results demonstrated that repirinast does not modify theophylline pharmacokinetics significantly.

Authors+Show Affiliations

Second Department of Internal Medicine, Saitama Medical School.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1650860

Citation

Nagata, M, et al. "[The Influence of Repirinast, an Anti-allergic Drug, On Theophylline Pharmacokinetics in Patients With Bronchial Asthma]." Nihon Kyobu Shikkan Gakkai Zasshi, vol. 29, no. 4, 1991, pp. 413-9.
Nagata M, Tabe K, Houya I, et al. [The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(4):413-9.
Nagata, M., Tabe, K., Houya, I., Kiuchi, H., Sakamoto, Y., Yamamoto, K., & Dohi, Y. (1991). [The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. Nihon Kyobu Shikkan Gakkai Zasshi, 29(4), pp. 413-9.
Nagata M, et al. [The Influence of Repirinast, an Anti-allergic Drug, On Theophylline Pharmacokinetics in Patients With Bronchial Asthma]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(4):413-9. PubMed PMID: 1650860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. AU - Nagata,M, AU - Tabe,K, AU - Houya,I, AU - Kiuchi,H, AU - Sakamoto,Y, AU - Yamamoto,K, AU - Dohi,Y, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 413 EP - 9 JF - Nihon Kyobu Shikkan Gakkai zasshi JO - Nihon Kyobu Shikkan Gakkai Zasshi VL - 29 IS - 4 N2 - In order to clarify whether repirinast, an inhibitor of chemical mediator release, could influence the pharmacokinetics of theophylline, a loading test using intravenous injection of aminophylline was performed in 10 subjects with bronchial asthma before and after treatment with 300 mg/day of repirinast. There was no significant difference in theophylline half-life before treatment (7.25 +/- 2.43 hr) and after treatment (7.82 +/- 3.35 hr). There was no significant difference in theophylline clearance before treatment (0.047 +/- 0.018 L/kg/hr) and after treatment (0.047 +/- 0.020 L/kg/hr). These results demonstrated that repirinast does not modify theophylline pharmacokinetics significantly. SN - 0301-1542 UR - https://www.unboundmedicine.com/medline/citation/1650860/[The_influence_of_repirinast_an_anti_allergic_drug_on_theophylline_pharmacokinetics_in_patients_with_bronchial_asthma]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -