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Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis.
Mol Carcinog. 2006 May; 45(5):309-19.MC

Abstract

Tea, one of the most widely consumed beverages worldwide, has been shown to have anti-cancer activity in various cancers including colon cancer. It has been demonstrated that overexpression of the inducible isoform of cyclooxygenase (COX-2) occurs during colon tumorigenesis and inhibition of COX-2 by non-steroidal anti-inflammatory drugs (NSAIDs) is chemopreventive. To determine whether the anti-cancer effect associated with green tea impacted COX-2 expression levels, human colorectal cancer cell lines HT-29 and HCA-7, were treated with (-)-epigallocatechin-3-gallate (EGCG), the most abundant and effective polyphenol of green tea. EGCG significantly inhibited constitutive COX-2 mRNA and protein overexpression. The inhibitory effects of EGCG on signaling pathways controlling COX-2 expression were examined. We observed that EGCG down regulated the ERK1/2 and Akt pathways in colon cancer cells. The effect of EGCG on COX-2 expression resulted in decreased COX-2 promoter activity via inhibition of nuclear factor kappaB (NF-kappaB) activation. EGCG also promoted rapid mRNA decay mediated through the COX-2 3'untranslated region (3'UTR). In conclusion, these data suggest that inhibition of COX-2 is a mechanism for the anti-proliferative effect of green tea and emphasizes the role that dietary factors have as anti-cancer agents.

Authors+Show Affiliations

Department of Pathology and Microbiology, School of Medicine, The University of South Carolina, and South Carolina Cancer Center, Columbia, South Carolina 29203, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16508969

Citation

Peng, Guang, et al. "Green Tea Polyphenol (-)-epigallocatechin-3-gallate Inhibits Cyclooxygenase-2 Expression in Colon Carcinogenesis." Molecular Carcinogenesis, vol. 45, no. 5, 2006, pp. 309-19.
Peng G, Dixon DA, Muga SJ, et al. Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Mol Carcinog. 2006;45(5):309-19.
Peng, G., Dixon, D. A., Muga, S. J., Smith, T. J., & Wargovich, M. J. (2006). Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Molecular Carcinogenesis, 45(5), 309-19.
Peng G, et al. Green Tea Polyphenol (-)-epigallocatechin-3-gallate Inhibits Cyclooxygenase-2 Expression in Colon Carcinogenesis. Mol Carcinog. 2006;45(5):309-19. PubMed PMID: 16508969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. AU - Peng,Guang, AU - Dixon,Dan A, AU - Muga,Stephanie J, AU - Smith,Theresa J, AU - Wargovich,Michael J, PY - 2006/3/2/pubmed PY - 2006/6/7/medline PY - 2006/3/2/entrez SP - 309 EP - 19 JF - Molecular carcinogenesis JO - Mol Carcinog VL - 45 IS - 5 N2 - Tea, one of the most widely consumed beverages worldwide, has been shown to have anti-cancer activity in various cancers including colon cancer. It has been demonstrated that overexpression of the inducible isoform of cyclooxygenase (COX-2) occurs during colon tumorigenesis and inhibition of COX-2 by non-steroidal anti-inflammatory drugs (NSAIDs) is chemopreventive. To determine whether the anti-cancer effect associated with green tea impacted COX-2 expression levels, human colorectal cancer cell lines HT-29 and HCA-7, were treated with (-)-epigallocatechin-3-gallate (EGCG), the most abundant and effective polyphenol of green tea. EGCG significantly inhibited constitutive COX-2 mRNA and protein overexpression. The inhibitory effects of EGCG on signaling pathways controlling COX-2 expression were examined. We observed that EGCG down regulated the ERK1/2 and Akt pathways in colon cancer cells. The effect of EGCG on COX-2 expression resulted in decreased COX-2 promoter activity via inhibition of nuclear factor kappaB (NF-kappaB) activation. EGCG also promoted rapid mRNA decay mediated through the COX-2 3'untranslated region (3'UTR). In conclusion, these data suggest that inhibition of COX-2 is a mechanism for the anti-proliferative effect of green tea and emphasizes the role that dietary factors have as anti-cancer agents. SN - 0899-1987 UR - https://www.unboundmedicine.com/medline/citation/16508969/Green_tea_polyphenol_____epigallocatechin_3_gallate_inhibits_cyclooxygenase_2_expression_in_colon_carcinogenesis_ L2 - https://doi.org/10.1002/mc.20166 DB - PRIME DP - Unbound Medicine ER -