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HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection.
J Gastroenterol Hepatol. 2006 Feb; 21(2):420-4.JG

Abstract

BACKGROUND AND AIMS

It has been suggested that the incidence of digestive diseases associated with Helicobacter pylori is influenced by the strain diversity of H. pylori, factors involving the host or environment, and the duration of infection. The authors have previously reported that human leukocyte antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development.

METHODS

HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. pylori-infected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, histological evaluation was performed.

RESULTS

The allele frequency of DQB1*0401 was significantly higher in intestinal type cancer patients compared with age- and sex-matched H. pylori-infected NUD patients. There was no significant difference in the mean atrophic scores of the biopsy samples from the lesser curvature of the mid-corpus between these groups.

CONCLUSIONS

HLA-DQB1*0401 is a useful marker for determining susceptibility to intestinal type gastric cancer.

Authors+Show Affiliations

Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University School of Medicine, Kobe, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16509868

Citation

Watanabe, Yoshinori, et al. "HLA-DQB1 Locus and Gastric Cancer in Helicobacter Pylori Infection." Journal of Gastroenterology and Hepatology, vol. 21, no. 2, 2006, pp. 420-4.
Watanabe Y, Aoyama N, Sakai T, et al. HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection. J Gastroenterol Hepatol. 2006;21(2):420-4.
Watanabe, Y., Aoyama, N., Sakai, T., Shirasaka, D., Maekawa, S., Kuroda, K., Wambura, C., Tamura, T., Nose, Y., & Kasuga, M. (2006). HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection. Journal of Gastroenterology and Hepatology, 21(2), 420-4.
Watanabe Y, et al. HLA-DQB1 Locus and Gastric Cancer in Helicobacter Pylori Infection. J Gastroenterol Hepatol. 2006;21(2):420-4. PubMed PMID: 16509868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection. AU - Watanabe,Yoshinori, AU - Aoyama,Nobuo, AU - Sakai,Toshiyuki, AU - Shirasaka,Daisuke, AU - Maekawa,Shuji, AU - Kuroda,Kohei, AU - Wambura,Casmir, AU - Tamura,Takao, AU - Nose,Yoshisuke, AU - Kasuga,Masato, PY - 2006/3/3/pubmed PY - 2006/8/2/medline PY - 2006/3/3/entrez SP - 420 EP - 4 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 21 IS - 2 N2 - BACKGROUND AND AIMS: It has been suggested that the incidence of digestive diseases associated with Helicobacter pylori is influenced by the strain diversity of H. pylori, factors involving the host or environment, and the duration of infection. The authors have previously reported that human leukocyte antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development. METHODS: HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. pylori-infected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, histological evaluation was performed. RESULTS: The allele frequency of DQB1*0401 was significantly higher in intestinal type cancer patients compared with age- and sex-matched H. pylori-infected NUD patients. There was no significant difference in the mean atrophic scores of the biopsy samples from the lesser curvature of the mid-corpus between these groups. CONCLUSIONS: HLA-DQB1*0401 is a useful marker for determining susceptibility to intestinal type gastric cancer. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/16509868/HLA_DQB1_locus_and_gastric_cancer_in_Helicobacter_pylori_infection_ L2 - https://doi.org/10.1111/j.1440-1746.2005.04112.x DB - PRIME DP - Unbound Medicine ER -