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Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei.
Brain Res. 2006 Apr 07; 1081(1):113-8.BR

Abstract

Immunohistochemistry for brain-derived neurotrophic factor (BDNF) was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 46% of TG neurons. These neurons were mostly small- or medium-sized (range, 149.7-1246.3 microm2; mean +/- SD = 373.4 +/- 151.6 microm2). A double immunofluorescence method also revealed that 54% of BDNF-immunoreactive (IR) neurons were immunoreactive for calcitonin-gene-related peptide. In addition, 93% of BDNF-IR TG neurons contained vanilloid receptor subtype 1. However, the co-expression of BDNF and vanilloid receptor 1-like receptor was very rare (less than 1%). In the trigeminal sensory nuclei, laminae II of the medullary dorsal horn was abundant in presumed BDNF-IR axon terminals. Such profiles were also detected in the dorsolateral part of the subnucleus oralis. The retrograde tracing and immunohistochemical methods demonstrated that BDNF-IR was common among cutaneous TG neurons (47%) but not tooth pulp TG neurons (13%). The present study indicates that BDNF-IR TG neurons have unmyelinated axons and project to the superficial medullary dorsal horn. It is likely that BDNF-containing neurons in both the trigeminal and spinal sensory systems have similarities in morphology and function. However, the content of BDNF in TG neurons probably depends on their peripheral targets. BDNF seems to convey nociceptive cutaneous input to the trigeminal sensory nuclei.

Authors+Show Affiliations

Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16510129

Citation

Ichikawa, H, et al. "Brain-derived Neurotrophic Factor-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion and Trigeminal Sensory Nuclei." Brain Research, vol. 1081, no. 1, 2006, pp. 113-8.
Ichikawa H, Yabuuchi T, Jin HW, et al. Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei. Brain Res. 2006;1081(1):113-8.
Ichikawa, H., Yabuuchi, T., Jin, H. W., Terayama, R., Yamaai, T., Deguchi, T., Kamioka, H., Takano-Yamamoto, T., & Sugimoto, T. (2006). Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei. Brain Research, 1081(1), 113-8.
Ichikawa H, et al. Brain-derived Neurotrophic Factor-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion and Trigeminal Sensory Nuclei. Brain Res. 2006 Apr 7;1081(1):113-8. PubMed PMID: 16510129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei. AU - Ichikawa,H, AU - Yabuuchi,T, AU - Jin,H W, AU - Terayama,R, AU - Yamaai,T, AU - Deguchi,T, AU - Kamioka,H, AU - Takano-Yamamoto,T, AU - Sugimoto,T, Y1 - 2006/02/28/ PY - 2005/09/25/received PY - 2006/01/04/revised PY - 2006/01/06/accepted PY - 2006/3/3/pubmed PY - 2006/7/11/medline PY - 2006/3/3/entrez SP - 113 EP - 8 JF - Brain research JO - Brain Res. VL - 1081 IS - 1 N2 - Immunohistochemistry for brain-derived neurotrophic factor (BDNF) was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 46% of TG neurons. These neurons were mostly small- or medium-sized (range, 149.7-1246.3 microm2; mean +/- SD = 373.4 +/- 151.6 microm2). A double immunofluorescence method also revealed that 54% of BDNF-immunoreactive (IR) neurons were immunoreactive for calcitonin-gene-related peptide. In addition, 93% of BDNF-IR TG neurons contained vanilloid receptor subtype 1. However, the co-expression of BDNF and vanilloid receptor 1-like receptor was very rare (less than 1%). In the trigeminal sensory nuclei, laminae II of the medullary dorsal horn was abundant in presumed BDNF-IR axon terminals. Such profiles were also detected in the dorsolateral part of the subnucleus oralis. The retrograde tracing and immunohistochemical methods demonstrated that BDNF-IR was common among cutaneous TG neurons (47%) but not tooth pulp TG neurons (13%). The present study indicates that BDNF-IR TG neurons have unmyelinated axons and project to the superficial medullary dorsal horn. It is likely that BDNF-containing neurons in both the trigeminal and spinal sensory systems have similarities in morphology and function. However, the content of BDNF in TG neurons probably depends on their peripheral targets. BDNF seems to convey nociceptive cutaneous input to the trigeminal sensory nuclei. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/16510129/Brain_derived_neurotrophic_factor_immunoreactive_primary_sensory_neurons_in_the_rat_trigeminal_ganglion_and_trigeminal_sensory_nuclei_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(06)00088-6 DB - PRIME DP - Unbound Medicine ER -