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Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.
Cancer Res. 2006 Mar 01; 66(5):2500-5.CR

Abstract

Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion that controls the unwanted proliferation of cells, thereby imparting strong cancer chemopreventive as well as therapeutic effects. This review discusses the modulations of important signaling events by EGCG and their implications in cancer management.

Authors+Show Affiliations

Department of Dermatology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16510563

Citation

Khan, Naghma, et al. "Targeting Multiple Signaling Pathways By Green Tea Polyphenol (-)-epigallocatechin-3-gallate." Cancer Research, vol. 66, no. 5, 2006, pp. 2500-5.
Khan N, Afaq F, Saleem M, et al. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 2006;66(5):2500-5.
Khan, N., Afaq, F., Saleem, M., Ahmad, N., & Mukhtar, H. (2006). Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Research, 66(5), 2500-5.
Khan N, et al. Targeting Multiple Signaling Pathways By Green Tea Polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 2006 Mar 1;66(5):2500-5. PubMed PMID: 16510563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. AU - Khan,Naghma, AU - Afaq,Farrukh, AU - Saleem,Mohammad, AU - Ahmad,Nihal, AU - Mukhtar,Hasan, PY - 2006/3/3/pubmed PY - 2006/4/19/medline PY - 2006/3/3/entrez SP - 2500 EP - 5 JF - Cancer research JO - Cancer Res VL - 66 IS - 5 N2 - Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion that controls the unwanted proliferation of cells, thereby imparting strong cancer chemopreventive as well as therapeutic effects. This review discusses the modulations of important signaling events by EGCG and their implications in cancer management. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/16510563/Targeting_multiple_signaling_pathways_by_green_tea_polyphenol_____epigallocatechin_3_gallate_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16510563 DB - PRIME DP - Unbound Medicine ER -