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Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial.
Pediatrics 2006; 117(3):620-5Ped

Abstract

BACKGROUND

The frequency of local vaccination reactions increases with successive doses of diphtheria-tetanus toxoids-acellular pertussis (DTaP) vaccine, and local reactions occur for the majority of children receiving the fifth DTaP vaccination. It is not known whether these reactions can be prevented with prophylactic use of acetaminophen or ibuprofen.

METHODS

In this 3-group, randomized, blinded, controlled trial, 372 children were assigned randomly, in a 2:2:1 ratio, to receive 3 doses of acetaminophen, ibuprofen, or placebo. The first dose of study medication was administered within 2 hours before the fifth DTaP vaccination, and the remaining 2 doses were given at 6-hour intervals. The primary outcome measures included a local reaction with an area of redness or discoloration > or =5 cm in diameter on the evening of or during the 2 days after vaccination, an increase in mid-limb circumference of > or =2 cm on the evening of or during the 2 days after vaccination, and a persistent local reaction, defined as an area of redness or discoloration present on the third day after vaccination.

RESULTS

Local reactions with a > or =5-cm area of redness or discoloration were reported for 35% of children in the placebo group, compared with 33% of children in the acetaminophen group and 37% of children in the ibuprofen group. There was also no significant difference between the placebo and treatment groups in the proportions of children with a > or =2-cm increase in mid-limb circumference or with a persistent local reaction.

CONCLUSIONS

We did not find evidence that prophylaxis with acetaminophen or ibuprofen offers a clinically significant benefit in prevention of local reactions to the fifth DTaP vaccination.

Authors+Show Affiliations

Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA. jackson.l@ghc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16510639

Citation

Jackson, Lisa A., et al. "Prophylaxis With Acetaminophen or Ibuprofen for Prevention of Local Reactions to the Fifth Diphtheria-tetanus Toxoids-acellular Pertussis Vaccination: a Randomized, Controlled Trial." Pediatrics, vol. 117, no. 3, 2006, pp. 620-5.
Jackson LA, Dunstan M, Starkovich P, et al. Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial. Pediatrics. 2006;117(3):620-5.
Jackson, L. A., Dunstan, M., Starkovich, P., Dunn, J., Yu, O., Nelson, J. C., ... Zavitkovsky, A. (2006). Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial. Pediatrics, 117(3), pp. 620-5.
Jackson LA, et al. Prophylaxis With Acetaminophen or Ibuprofen for Prevention of Local Reactions to the Fifth Diphtheria-tetanus Toxoids-acellular Pertussis Vaccination: a Randomized, Controlled Trial. Pediatrics. 2006;117(3):620-5. PubMed PMID: 16510639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial. AU - Jackson,Lisa A, AU - Dunstan,Maya, AU - Starkovich,Patty, AU - Dunn,John, AU - Yu,Onchee, AU - Nelson,Jennifer C, AU - Rees,Thom, AU - Zavitkovsky,Ann, PY - 2006/3/3/pubmed PY - 2006/3/23/medline PY - 2006/3/3/entrez SP - 620 EP - 5 JF - Pediatrics JO - Pediatrics VL - 117 IS - 3 N2 - BACKGROUND: The frequency of local vaccination reactions increases with successive doses of diphtheria-tetanus toxoids-acellular pertussis (DTaP) vaccine, and local reactions occur for the majority of children receiving the fifth DTaP vaccination. It is not known whether these reactions can be prevented with prophylactic use of acetaminophen or ibuprofen. METHODS: In this 3-group, randomized, blinded, controlled trial, 372 children were assigned randomly, in a 2:2:1 ratio, to receive 3 doses of acetaminophen, ibuprofen, or placebo. The first dose of study medication was administered within 2 hours before the fifth DTaP vaccination, and the remaining 2 doses were given at 6-hour intervals. The primary outcome measures included a local reaction with an area of redness or discoloration > or =5 cm in diameter on the evening of or during the 2 days after vaccination, an increase in mid-limb circumference of > or =2 cm on the evening of or during the 2 days after vaccination, and a persistent local reaction, defined as an area of redness or discoloration present on the third day after vaccination. RESULTS: Local reactions with a > or =5-cm area of redness or discoloration were reported for 35% of children in the placebo group, compared with 33% of children in the acetaminophen group and 37% of children in the ibuprofen group. There was also no significant difference between the placebo and treatment groups in the proportions of children with a > or =2-cm increase in mid-limb circumference or with a persistent local reaction. CONCLUSIONS: We did not find evidence that prophylaxis with acetaminophen or ibuprofen offers a clinically significant benefit in prevention of local reactions to the fifth DTaP vaccination. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/16510639/Prophylaxis_with_acetaminophen_or_ibuprofen_for_prevention_of_local_reactions_to_the_fifth_diphtheria_tetanus_toxoids_acellular_pertussis_vaccination:_a_randomized_controlled_trial_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=16510639 DB - PRIME DP - Unbound Medicine ER -