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CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens.
Eur J Immunol 2006; 36(4):855-63EJ

Abstract

CD4+ CD25+ T reg cells are critical for peripheral tolerance and prevention of autoimmunity. Here we show that CD4+ CD25+ T reg also regulate the magnitude of humoral responses against a panel of T-dependent antigens of foreign origin during both primary and secondary immune responses. Depletion of CD4+ CD25+ T cells leads to increased antigen-specific antibody production and affinity maturation but does not affect T-independent B cell responses, suggesting that CD4+ CD25+ T reg exert a feedback mechanism on non-self antigen-specific antibody secretion by dampening the T cell help for B cell activation. Moreover, we show that CD4+ CD25+ T reg also suppress in vitro B cell immunoglobulin production by inhibiting CD4+ CD25- T cell help delivery, and that blockade of TGF-beta activity abolishes this suppression.

Authors+Show Affiliations

Laboratoire de Physiologie animale, Université Libre de Bruxelles, Gosselies, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16511897

Citation

Eddahri, Fouad, et al. "CD4+ CD25+ Regulatory T Cells Control the Magnitude of T-dependent Humoral Immune Responses to Exogenous Antigens." European Journal of Immunology, vol. 36, no. 4, 2006, pp. 855-63.
Eddahri F, Oldenhove G, Denanglaire S, et al. CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. Eur J Immunol. 2006;36(4):855-63.
Eddahri, F., Oldenhove, G., Denanglaire, S., Urbain, J., Leo, O., & Andris, F. (2006). CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. European Journal of Immunology, 36(4), pp. 855-63.
Eddahri F, et al. CD4+ CD25+ Regulatory T Cells Control the Magnitude of T-dependent Humoral Immune Responses to Exogenous Antigens. Eur J Immunol. 2006;36(4):855-63. PubMed PMID: 16511897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. AU - Eddahri,Fouad, AU - Oldenhove,Guillaume, AU - Denanglaire,Sébastien, AU - Urbain,Jacques, AU - Leo,Oberdan, AU - Andris,Fabienne, PY - 2006/3/3/pubmed PY - 2006/5/19/medline PY - 2006/3/3/entrez SP - 855 EP - 63 JF - European journal of immunology JO - Eur. J. Immunol. VL - 36 IS - 4 N2 - CD4+ CD25+ T reg cells are critical for peripheral tolerance and prevention of autoimmunity. Here we show that CD4+ CD25+ T reg also regulate the magnitude of humoral responses against a panel of T-dependent antigens of foreign origin during both primary and secondary immune responses. Depletion of CD4+ CD25+ T cells leads to increased antigen-specific antibody production and affinity maturation but does not affect T-independent B cell responses, suggesting that CD4+ CD25+ T reg exert a feedback mechanism on non-self antigen-specific antibody secretion by dampening the T cell help for B cell activation. Moreover, we show that CD4+ CD25+ T reg also suppress in vitro B cell immunoglobulin production by inhibiting CD4+ CD25- T cell help delivery, and that blockade of TGF-beta activity abolishes this suppression. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/16511897/CD4+_CD25+_regulatory_T_cells_control_the_magnitude_of_T_dependent_humoral_immune_responses_to_exogenous_antigens_ L2 - https://doi.org/10.1002/eji.200535500 DB - PRIME DP - Unbound Medicine ER -