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Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years.
Allergy. 2006 Apr; 61(4):431-7.A

Abstract

BACKGROUND

Appropriate use of prebiotics and optimal combinations of probiotics and prebiotics (synbiotics) could allow significantly better results to be obtained in the treatment of atopic dermatitis (AD).

OBJECTIVE

To evaluate the efficiency of synbiotics when compared with prebiotics alone (control group) in the treatment of moderate and severe AD in children aged 2 years and over.

METHODS

Double-blind prospective randomized study performed on children aged at least 2 years presenting AD with a minimum SCORing Atopic Dermatitis (SCORAD) score of 15. A dose of 1.2 x 10(9) colony-forming units Lactobacillus rhamnosus Lcr35 plus prebiotic preparation or an identically appearing prebiotic preparation alone was given three times a day for 3 months. Patients' diet and usual treatment for AD remained unchanged during the study period. Efficiency was evaluated using the SCORAD score. Use of topical drugs was noted.

RESULTS

A total of 48 patients were originally enrolled; nine did not complete the study. In synbiotic group, the mean values of the total SCORAD score was 39.1 before treatment vs 20.7 after 3 months of treatment (P < 0.0001). In the prebiotic group, the mean of the total SCORAD score was 39.3 before the treatment vs 24.0 after 3 months (P < 0.0001). After 3 months of treatment, no statistical differences between the two treatment groups with regard to the total SCORAD score were noted (P = 0.535). Neither were there any statistical differences in the total use of ointment between patients receiving prebiotics or synbiotics (P = 0.966) over the study period. Tolerance was excellent in both groups.

CONCLUSIONS

Both synbiotics and prebiotics used alone seem able to significantly improve the manifestations of AD in children aged 2 years and over.

Authors+Show Affiliations

Department of Dermatology, CHU de Nice, Nice, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16512804

Citation

Passeron, T, et al. "Prebiotics and Synbiotics: Two Promising Approaches for the Treatment of Atopic Dermatitis in Children Above 2 Years." Allergy, vol. 61, no. 4, 2006, pp. 431-7.
Passeron T, Lacour JP, Fontas E, et al. Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. Allergy. 2006;61(4):431-7.
Passeron, T., Lacour, J. P., Fontas, E., & Ortonne, J. P. (2006). Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. Allergy, 61(4), 431-7.
Passeron T, et al. Prebiotics and Synbiotics: Two Promising Approaches for the Treatment of Atopic Dermatitis in Children Above 2 Years. Allergy. 2006;61(4):431-7. PubMed PMID: 16512804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. AU - Passeron,T, AU - Lacour,J-P, AU - Fontas,E, AU - Ortonne,J-P, PY - 2006/3/4/pubmed PY - 2006/8/24/medline PY - 2006/3/4/entrez SP - 431 EP - 7 JF - Allergy JO - Allergy VL - 61 IS - 4 N2 - BACKGROUND: Appropriate use of prebiotics and optimal combinations of probiotics and prebiotics (synbiotics) could allow significantly better results to be obtained in the treatment of atopic dermatitis (AD). OBJECTIVE: To evaluate the efficiency of synbiotics when compared with prebiotics alone (control group) in the treatment of moderate and severe AD in children aged 2 years and over. METHODS: Double-blind prospective randomized study performed on children aged at least 2 years presenting AD with a minimum SCORing Atopic Dermatitis (SCORAD) score of 15. A dose of 1.2 x 10(9) colony-forming units Lactobacillus rhamnosus Lcr35 plus prebiotic preparation or an identically appearing prebiotic preparation alone was given three times a day for 3 months. Patients' diet and usual treatment for AD remained unchanged during the study period. Efficiency was evaluated using the SCORAD score. Use of topical drugs was noted. RESULTS: A total of 48 patients were originally enrolled; nine did not complete the study. In synbiotic group, the mean values of the total SCORAD score was 39.1 before treatment vs 20.7 after 3 months of treatment (P < 0.0001). In the prebiotic group, the mean of the total SCORAD score was 39.3 before the treatment vs 24.0 after 3 months (P < 0.0001). After 3 months of treatment, no statistical differences between the two treatment groups with regard to the total SCORAD score were noted (P = 0.535). Neither were there any statistical differences in the total use of ointment between patients receiving prebiotics or synbiotics (P = 0.966) over the study period. Tolerance was excellent in both groups. CONCLUSIONS: Both synbiotics and prebiotics used alone seem able to significantly improve the manifestations of AD in children aged 2 years and over. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/16512804/Prebiotics_and_synbiotics:_two_promising_approaches_for_the_treatment_of_atopic_dermatitis_in_children_above_2_years_ L2 - https://doi.org/10.1111/j.1398-9995.2005.00956.x DB - PRIME DP - Unbound Medicine ER -