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Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study.
Br J Nutr 2006; 95(3):539-45BJ

Abstract

Although dairy products have been found to be associated with an elevated risk of prostate cancer, studies investigating the potential effect of Ca are limited, and findings are inconsistent. The objective of the present study was to test the relationship between the risk of prostate cancer and consumption of dairy products and Ca. The analysis included 2776 men from the French SU.VI.MAX (Supplementation en Vitamines et Minéraux Antioxydants) prospective study, among whom sixty-nine developed prostate cancer during the follow-up period (median: 7.7 years). Food consumption was assessed at inclusion from repeated 24 h records and nutrient intake was calculated using a food composition table. A higher risk of prostate cancer was observed among subjects with higher dairy product (relative risk (RR; 95 % CI), 4th quartile v. 1st: 1.35 (1.02, 1.78), P = 0.04) and Ca intake (RR (95 % CI), 4th quartile v. 1st: 2.43 (1.05, 5.62), P = 0.04). Nevertheless, we identified a harmful effect of yoghurt consumption upon the risk of prostate cancer (RR (95 % CI), increment 125 g/d: 1.61 (1.07, 2.43), P = 0.02) independently of the Ca content. Our data support the hypothesis that dairy products have a harmful effect with respect to the risk of prostate cancer, largely related to Ca content. The higher risk of prostate cancer with linear increasing yoghurt consumption seems to be independent of Ca and may be related to some other component.

Authors+Show Affiliations

Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, Paris, France. emmanuelle.kesse@cnam.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16512941

Citation

Kesse, E, et al. "Dairy Products, Calcium and Phosphorus Intake, and the Risk of Prostate Cancer: Results of the French Prospective SU.VI.MAX (Supplémentation En Vitamines Et Minéraux Antioxydants) Study." The British Journal of Nutrition, vol. 95, no. 3, 2006, pp. 539-45.
Kesse E, Bertrais S, Astorg P, et al. Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. Br J Nutr. 2006;95(3):539-45.
Kesse, E., Bertrais, S., Astorg, P., Jaouen, A., Arnault, N., Galan, P., & Hercberg, S. (2006). Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. The British Journal of Nutrition, 95(3), pp. 539-45.
Kesse E, et al. Dairy Products, Calcium and Phosphorus Intake, and the Risk of Prostate Cancer: Results of the French Prospective SU.VI.MAX (Supplémentation En Vitamines Et Minéraux Antioxydants) Study. Br J Nutr. 2006;95(3):539-45. PubMed PMID: 16512941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. AU - Kesse,E, AU - Bertrais,S, AU - Astorg,P, AU - Jaouen,A, AU - Arnault,N, AU - Galan,P, AU - Hercberg,S, PY - 2006/3/4/pubmed PY - 2006/5/9/medline PY - 2006/3/4/entrez SP - 539 EP - 45 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 95 IS - 3 N2 - Although dairy products have been found to be associated with an elevated risk of prostate cancer, studies investigating the potential effect of Ca are limited, and findings are inconsistent. The objective of the present study was to test the relationship between the risk of prostate cancer and consumption of dairy products and Ca. The analysis included 2776 men from the French SU.VI.MAX (Supplementation en Vitamines et Minéraux Antioxydants) prospective study, among whom sixty-nine developed prostate cancer during the follow-up period (median: 7.7 years). Food consumption was assessed at inclusion from repeated 24 h records and nutrient intake was calculated using a food composition table. A higher risk of prostate cancer was observed among subjects with higher dairy product (relative risk (RR; 95 % CI), 4th quartile v. 1st: 1.35 (1.02, 1.78), P = 0.04) and Ca intake (RR (95 % CI), 4th quartile v. 1st: 2.43 (1.05, 5.62), P = 0.04). Nevertheless, we identified a harmful effect of yoghurt consumption upon the risk of prostate cancer (RR (95 % CI), increment 125 g/d: 1.61 (1.07, 2.43), P = 0.02) independently of the Ca content. Our data support the hypothesis that dairy products have a harmful effect with respect to the risk of prostate cancer, largely related to Ca content. The higher risk of prostate cancer with linear increasing yoghurt consumption seems to be independent of Ca and may be related to some other component. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/16512941/Dairy_products_calcium_and_phosphorus_intake_and_the_risk_of_prostate_cancer:_results_of_the_French_prospective_SU_VI_MAX__Supplémentation_en_Vitamines_et_Minéraux_Antioxydants__study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114506000730/type/journal_article DB - PRIME DP - Unbound Medicine ER -