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Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats.
Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R736-41.AJ

Abstract

Previous studies have shown that the sympathetically mediated oscillations of arterial pressure (AP), the so-called Mayer waves, are shifted from 0.4 to 0.6 Hz after acute alpha-adrenoceptor blockade in conscious rats. This raises the possibility that, under physiological conditions, Mayer waves are mediated by the conjoint action of norepinephrine and other sympathetic cotransmitters. To evaluate the possible role of the cotransmitter ATP in determining the frequency of Mayer waves, AP and renal sympathetic nerve activity (RSNA) were simultaneously recorded in 10 conscious rats with cardiac autonomic blockade before and after acute blockade of P2 receptors with pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid. P2 receptor blockade did not alter the mean level and overall variability of AP and RSNA but shifted peak coherence between AP and RSNA from 0.43 +/- 0.02 to 0.22 +/- 0.01 Hz. A model of the sympathetic limb of the arterial baroreceptor reflex was designed to simulate Mayer waves at 0.2 and 0.6 Hz, with norepinephrine and ATP, respectively, acting as the sole sympathetic cotransmitter. When both cotransmitters acted in concert, a single oscillation was observed at 0.4 Hz when the gain ratio of the adrenergic to the purinergic components was set at 15. The model thus accounted for an important role for ATP in determining Mayer wave frequency, but not in sustaining the mean level of AP or controlling its overall variability.

Authors+Show Affiliations

Département de Physiologie et Pharmacologie Clinique, Université Lyon, 69373 Lyon Cedex 08, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16513767

Citation

Emonnot, Léa, et al. "Role of Purinergic Cotransmission in the Sympathetic Control of Arterial Pressure Variability in Conscious Rats." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 291, no. 3, 2006, pp. R736-41.
Emonnot L, Bakhos C, Chapuis B, et al. Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2006;291(3):R736-41.
Emonnot, L., Bakhos, C., Chapuis, B., Oréa, V., Barrès, C., & Julien, C. (2006). Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 291(3), R736-41.
Emonnot L, et al. Role of Purinergic Cotransmission in the Sympathetic Control of Arterial Pressure Variability in Conscious Rats. Am J Physiol Regul Integr Comp Physiol. 2006;291(3):R736-41. PubMed PMID: 16513767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats. AU - Emonnot,Léa, AU - Bakhos,Charles, AU - Chapuis,Bruno, AU - Oréa,Valérie, AU - Barrès,Christian, AU - Julien,Claude, Y1 - 2006/03/02/ PY - 2006/3/4/pubmed PY - 2006/9/21/medline PY - 2006/3/4/entrez SP - R736 EP - 41 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 291 IS - 3 N2 - Previous studies have shown that the sympathetically mediated oscillations of arterial pressure (AP), the so-called Mayer waves, are shifted from 0.4 to 0.6 Hz after acute alpha-adrenoceptor blockade in conscious rats. This raises the possibility that, under physiological conditions, Mayer waves are mediated by the conjoint action of norepinephrine and other sympathetic cotransmitters. To evaluate the possible role of the cotransmitter ATP in determining the frequency of Mayer waves, AP and renal sympathetic nerve activity (RSNA) were simultaneously recorded in 10 conscious rats with cardiac autonomic blockade before and after acute blockade of P2 receptors with pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid. P2 receptor blockade did not alter the mean level and overall variability of AP and RSNA but shifted peak coherence between AP and RSNA from 0.43 +/- 0.02 to 0.22 +/- 0.01 Hz. A model of the sympathetic limb of the arterial baroreceptor reflex was designed to simulate Mayer waves at 0.2 and 0.6 Hz, with norepinephrine and ATP, respectively, acting as the sole sympathetic cotransmitter. When both cotransmitters acted in concert, a single oscillation was observed at 0.4 Hz when the gain ratio of the adrenergic to the purinergic components was set at 15. The model thus accounted for an important role for ATP in determining Mayer wave frequency, but not in sustaining the mean level of AP or controlling its overall variability. SN - 0363-6119 UR - https://www.unboundmedicine.com/medline/citation/16513767/Role_of_purinergic_cotransmission_in_the_sympathetic_control_of_arterial_pressure_variability_in_conscious_rats_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.00088.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -