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Clinical and cytologic features of papillary neoplasms of the breast.
Acta Cytol. 2006 Jan-Feb; 50(1):35-40.AC

Abstract

OBJECTIVE

To compare the cytologic features benign and malignant papillary breast lesions.

STUDY DESIGN

We reviewed the clinical and cytologic features in 29 cases of intraductal papilloma and 26 cases of atypical papilloma or papillary carcinoma that had been diagnosed by histologic examination. The diameter of the mass was examined as a clinical feature. The cytologic features evaluated were as follows: bloody background, row of tall columnar cells, naked bipolar nuclei, hemosiderin-laden macrophages, myoepithelial cells, single scattered atypical cells, cellularity, nuclear atypia, nuclear grade, apocrine metaplasia, eosinophilic cytoplasmic granules, papillary clusters, small papillae, cell balls and large sheets.

RESULTS

Of the features evaluated, the diameter of the mass, naked bipolar nuclei and cell balls differed significantly between benign and atypical or malignant papillary neoplasms. The average diameter of a benign papillary neoplasm was 1.8 cm, and that of an atypical or malignant papillary neoplasm was 2.2 cm (p = 0.042). Naked bipolar nuclei were found in 27 cases of benign papillary neoplasm (93.1%) versus 19 cases of atypical or malignant papillary neoplasm (73.1%) (p = 0.050). Cell balls were found in 14 (48.3%) and 21 (80.8%) cases, respectively (p = 0.012). All 6 cases in which cell balls were present and naked bipolar nuclei were absent proved to be atypical or malignant papillary neoplasms. Of 17 cases in which cell balls were absent and naked bipolar nuclei present, 13 (76.5%) were benign papillary neoplasms.

CONCLUSION

Most cytologic features overlapped in benign and atypical or malignant papillary neoplasms. Although they were not pathognomonic, naked bipolar nuclei and cell balls were cytologic features that differed significantly between benign and atypical or malignant papillary neoplasms. When papillary neoplasms of the breast are suspected in a cytologic smear, the combination of clinical examination, mammography and cytologic features should be considered to make the correct diagnosis.

Authors+Show Affiliations

Departments of Pathology, Chonnam National University Hospital, Gwangju, Republic of Korea. cchoi@jnu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16514838

Citation

Choi, Yoo Duk, et al. "Clinical and Cytologic Features of Papillary Neoplasms of the Breast." Acta Cytologica, vol. 50, no. 1, 2006, pp. 35-40.
Choi YD, Gong GY, Kim MJ, et al. Clinical and cytologic features of papillary neoplasms of the breast. Acta Cytol. 2006;50(1):35-40.
Choi, Y. D., Gong, G. Y., Kim, M. J., Lee, J. S., Nam, J. H., Juhng, S. W., & Choi, C. (2006). Clinical and cytologic features of papillary neoplasms of the breast. Acta Cytologica, 50(1), 35-40.
Choi YD, et al. Clinical and Cytologic Features of Papillary Neoplasms of the Breast. Acta Cytol. 2006 Jan-Feb;50(1):35-40. PubMed PMID: 16514838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and cytologic features of papillary neoplasms of the breast. AU - Choi,Yoo Duk, AU - Gong,Gyung Yub, AU - Kim,Mi Jung, AU - Lee,Ji Shin, AU - Nam,Jong Hee, AU - Juhng,Sang-Woo, AU - Choi,Chan, PY - 2006/3/7/pubmed PY - 2006/3/24/medline PY - 2006/3/7/entrez SP - 35 EP - 40 JF - Acta cytologica JO - Acta Cytol VL - 50 IS - 1 N2 - OBJECTIVE: To compare the cytologic features benign and malignant papillary breast lesions. STUDY DESIGN: We reviewed the clinical and cytologic features in 29 cases of intraductal papilloma and 26 cases of atypical papilloma or papillary carcinoma that had been diagnosed by histologic examination. The diameter of the mass was examined as a clinical feature. The cytologic features evaluated were as follows: bloody background, row of tall columnar cells, naked bipolar nuclei, hemosiderin-laden macrophages, myoepithelial cells, single scattered atypical cells, cellularity, nuclear atypia, nuclear grade, apocrine metaplasia, eosinophilic cytoplasmic granules, papillary clusters, small papillae, cell balls and large sheets. RESULTS: Of the features evaluated, the diameter of the mass, naked bipolar nuclei and cell balls differed significantly between benign and atypical or malignant papillary neoplasms. The average diameter of a benign papillary neoplasm was 1.8 cm, and that of an atypical or malignant papillary neoplasm was 2.2 cm (p = 0.042). Naked bipolar nuclei were found in 27 cases of benign papillary neoplasm (93.1%) versus 19 cases of atypical or malignant papillary neoplasm (73.1%) (p = 0.050). Cell balls were found in 14 (48.3%) and 21 (80.8%) cases, respectively (p = 0.012). All 6 cases in which cell balls were present and naked bipolar nuclei were absent proved to be atypical or malignant papillary neoplasms. Of 17 cases in which cell balls were absent and naked bipolar nuclei present, 13 (76.5%) were benign papillary neoplasms. CONCLUSION: Most cytologic features overlapped in benign and atypical or malignant papillary neoplasms. Although they were not pathognomonic, naked bipolar nuclei and cell balls were cytologic features that differed significantly between benign and atypical or malignant papillary neoplasms. When papillary neoplasms of the breast are suspected in a cytologic smear, the combination of clinical examination, mammography and cytologic features should be considered to make the correct diagnosis. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/16514838/Clinical_and_cytologic_features_of_papillary_neoplasms_of_the_breast_ L2 - https://www.karger.com?DOI=10.1159/000325892 DB - PRIME DP - Unbound Medicine ER -