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Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker.
J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8.JT

Abstract

OBJECTIVES

B-type natriuretic peptide, a cardiac hormone with diuretic, natriuretic, and vasoactive properties, is used in the diagnosis, risk stratification, and management of adult cardiac patients. However, no study has yet determined the prognostic value of B-type natriuretic peptide after surgical intervention for congenital heart disease. The objectives of this study were (1) to determine alterations in B-type natriuretic peptide levels after repair of congenital heart disease with cardiopulmonary bypass and (2) to investigate potential associations between B-type natriuretic peptide levels and outcomes in this patient population.

METHODS

Fifty-one infants and children undergoing repair of congenital heart disease were studied. B-type natriuretic peptide levels were measured before and after surgical intervention, and the ability of the postoperative 12-hour B-type natriuretic peptide level to predict postoperative outcomes was evaluated.

RESULTS

B-type natriuretic peptide levels increased after separation from cardiopulmonary bypass, with an 8-fold peak increase at 12 hours (P < .005). Postoperative 12-hour B-type natriuretic peptide levels were associated with the duration of mechanical ventilation and the presence of a low cardiac output state after surgical intervention. On multivariate analysis, the 12-hour B-type natriuretic peptide level was an independent predictor of the duration of mechanical ventilation. In fact, B-type natriuretic peptide levels of greater than 540 pg/mL predicted mechanical ventilation beyond 48 hours, with a sensitivity of 88.9% and a specificity of 82.5%. In addition, B-type natriuretic peptide levels of greater than 815 pg/mL predicted the presence of a low cardiac output state within 48 hours after surgical intervention, with a sensitivity of 87.5% and a specificity of 90.2%.

CONCLUSIONS

B-type natriuretic peptide determinations might be a useful tool for clinicians caring for infants and children after surgical intervention for congenital heart disease.

Authors+Show Affiliations

Department of Pediatrics, University of California, San Francisco, Calif, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16515916

Citation

Shih, Chie-Youn, et al. "Alterations in Plasma B-type Natriuretic Peptide Levels After Repair of Congenital Heart Defects: a Potential Perioperative Marker." The Journal of Thoracic and Cardiovascular Surgery, vol. 131, no. 3, 2006, pp. 632-8.
Shih CY, Sapru A, Oishi P, et al. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006;131(3):632-8.
Shih, C. Y., Sapru, A., Oishi, P., Azakie, A., Karl, T. R., Harmon, C., Asija, R., Adatia, I., & Fineman, J. R. (2006). Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. The Journal of Thoracic and Cardiovascular Surgery, 131(3), 632-8.
Shih CY, et al. Alterations in Plasma B-type Natriuretic Peptide Levels After Repair of Congenital Heart Defects: a Potential Perioperative Marker. J Thorac Cardiovasc Surg. 2006;131(3):632-8. PubMed PMID: 16515916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. AU - Shih,Chie-Youn, AU - Sapru,Anil, AU - Oishi,Peter, AU - Azakie,Anthony, AU - Karl,Tom R, AU - Harmon,Cynthia, AU - Asija,Ritu, AU - Adatia,Ian, AU - Fineman,Jeffrey R, PY - 2005/09/23/received PY - 2005/10/26/revised PY - 2005/10/31/accepted PY - 2006/3/7/pubmed PY - 2006/5/16/medline PY - 2006/3/7/entrez SP - 632 EP - 8 JF - The Journal of thoracic and cardiovascular surgery JO - J Thorac Cardiovasc Surg VL - 131 IS - 3 N2 - OBJECTIVES: B-type natriuretic peptide, a cardiac hormone with diuretic, natriuretic, and vasoactive properties, is used in the diagnosis, risk stratification, and management of adult cardiac patients. However, no study has yet determined the prognostic value of B-type natriuretic peptide after surgical intervention for congenital heart disease. The objectives of this study were (1) to determine alterations in B-type natriuretic peptide levels after repair of congenital heart disease with cardiopulmonary bypass and (2) to investigate potential associations between B-type natriuretic peptide levels and outcomes in this patient population. METHODS: Fifty-one infants and children undergoing repair of congenital heart disease were studied. B-type natriuretic peptide levels were measured before and after surgical intervention, and the ability of the postoperative 12-hour B-type natriuretic peptide level to predict postoperative outcomes was evaluated. RESULTS: B-type natriuretic peptide levels increased after separation from cardiopulmonary bypass, with an 8-fold peak increase at 12 hours (P < .005). Postoperative 12-hour B-type natriuretic peptide levels were associated with the duration of mechanical ventilation and the presence of a low cardiac output state after surgical intervention. On multivariate analysis, the 12-hour B-type natriuretic peptide level was an independent predictor of the duration of mechanical ventilation. In fact, B-type natriuretic peptide levels of greater than 540 pg/mL predicted mechanical ventilation beyond 48 hours, with a sensitivity of 88.9% and a specificity of 82.5%. In addition, B-type natriuretic peptide levels of greater than 815 pg/mL predicted the presence of a low cardiac output state within 48 hours after surgical intervention, with a sensitivity of 87.5% and a specificity of 90.2%. CONCLUSIONS: B-type natriuretic peptide determinations might be a useful tool for clinicians caring for infants and children after surgical intervention for congenital heart disease. SN - 1097-685X UR - https://www.unboundmedicine.com/medline/citation/16515916/Alterations_in_plasma_B_type_natriuretic_peptide_levels_after_repair_of_congenital_heart_defects:_a_potential_perioperative_marker_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5223(05)01921-5 DB - PRIME DP - Unbound Medicine ER -