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Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease.
Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1034-9.BB

Abstract

We have used quantitative 2D gel electrophoresis to analyze serum proteins from 422 patients with neurodegenerative diseases and normal individuals in an unbiased approach to identify biomarkers. Differences in abnormal serum levels were found between amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and related disorders for 34 protein biomarker spots, nine of which were related to the complement system. Of these nine, four spots originated from the Complement C3b-alpha-chain (C3c(1), C3c(2a), C3c(2b), and C3dg). The C3c spots (C3c(1), C3c(2a), and C3c(2b)) had the same amino acid sequence and glycosylation, though only C3c(1) was phosphorylated. In addition, Complement Factors H, Bb, and Pre-Serum amyloid protein displayed different serum concentrations in ALS, PD, and normal sera, whereas Complement C4b gamma-chain and Complement Factor I did not. The differential expression of the complement proteins provides potentially useful biomarkers as well as evidence for the involvement of inflammatory processes in the pathogenesis of ALS and PD.

Authors+Show Affiliations

Goldknopf IL
Power3 Medical Products, Inc., The Woodlands, TX, USA. igoldknopf@power3.medical.com
Sheta EA
No affiliation info available
Bryson J
No affiliation info available
Folsom B
No affiliation info available
Wilson C
No affiliation info available
Duty J
No affiliation info available
Yen AA
No affiliation info available
Appel SH
No affiliation info available

MeSH

Amyotrophic Lateral SclerosisBiomarkersBlood ProteinsComplement C3cHumansParkinson DiseaseRisk AssessmentRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16516157

Clinical Trial Links

Amyotrophic Lateral Sclerosis and the Innate Immune System

Citation

Goldknopf, Ira L., et al. "Complement C3c and Related Protein Biomarkers in Amyotrophic Lateral Sclerosis and Parkinson's Disease." Biochemical and Biophysical Research Communications, vol. 342, no. 4, 2006, pp. 1034-9.
Goldknopf IL, Sheta EA, Bryson J, et al. Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. Biochem Biophys Res Commun. 2006;342(4):1034-9.
Goldknopf, I. L., Sheta, E. A., Bryson, J., Folsom, B., Wilson, C., Duty, J., Yen, A. A., & Appel, S. H. (2006). Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. Biochemical and Biophysical Research Communications, 342(4), 1034-9.
Goldknopf IL, et al. Complement C3c and Related Protein Biomarkers in Amyotrophic Lateral Sclerosis and Parkinson's Disease. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1034-9. PubMed PMID: 16516157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. AU - Goldknopf,Ira L, AU - Sheta,Essam A, AU - Bryson,Jennifer, AU - Folsom,Brian, AU - Wilson,Chris, AU - Duty,Jeff, AU - Yen,Albert A, AU - Appel,Stanley H, Y1 - 2006/02/20/ PY - 2006/02/03/received PY - 2006/02/09/accepted PY - 2006/3/7/pubmed PY - 2006/5/5/medline PY - 2006/3/7/entrez SP - 1034 EP - 9 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 342 IS - 4 N2 - We have used quantitative 2D gel electrophoresis to analyze serum proteins from 422 patients with neurodegenerative diseases and normal individuals in an unbiased approach to identify biomarkers. Differences in abnormal serum levels were found between amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and related disorders for 34 protein biomarker spots, nine of which were related to the complement system. Of these nine, four spots originated from the Complement C3b-alpha-chain (C3c(1), C3c(2a), C3c(2b), and C3dg). The C3c spots (C3c(1), C3c(2a), and C3c(2b)) had the same amino acid sequence and glycosylation, though only C3c(1) was phosphorylated. In addition, Complement Factors H, Bb, and Pre-Serum amyloid protein displayed different serum concentrations in ALS, PD, and normal sera, whereas Complement C4b gamma-chain and Complement Factor I did not. The differential expression of the complement proteins provides potentially useful biomarkers as well as evidence for the involvement of inflammatory processes in the pathogenesis of ALS and PD. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16516157/Complement_C3c_and_related_protein_biomarkers_in_amyotrophic_lateral_sclerosis_and_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -