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t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge.
J Nutr Biochem. 2006 Nov; 17(11):735-41.JN

Abstract

Previous work demonstrated that feeding commercial preparations of conjugated linoleic acid (CLA) [a 50:50 mixture of c9,t11 and t10,c12 CLA (cCLA)] partially overcame lipopolysaccharide (LPS)-induced growth depression. The objective of this study was to determine which CLA isomer was responsible for the reduction of LPS-induced growth depression. Dietary cCLA supplementation for 3 weeks protected mice from LPS-induced weight loss 24 h after injection compared to mice fed isocaloric and isonitrogenous control diets supplemented with either corn oil (CO) or a mixture of CO and olive oil. Dietary c9,t11 or t10,c12 CLA led to body weight loss intermediate to controls and cCLA. After LPS-induced weight loss, the t10,c12 CLA fed mice regained weight faster than the control or c9,t11 CLA fed mice. Dietary t10,c12 CLA and cCLA reduced plasma tumor necrosis factor 2 h after LPS stimulation. While neither c9,t11 nor t10,c12 CLA isomers alone protected from immune-induced weight loss, the t10,c12 CLA isomer induced compensatory gain.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16517148

Citation

Butz, Daniel E., et al. "T10,c12 Conjugated Linoleic Acid Induces Compensatory Growth After Immune Challenge." The Journal of Nutritional Biochemistry, vol. 17, no. 11, 2006, pp. 735-41.
Butz DE, Li G, Cook ME. T10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. J Nutr Biochem. 2006;17(11):735-41.
Butz, D. E., Li, G., & Cook, M. E. (2006). T10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. The Journal of Nutritional Biochemistry, 17(11), 735-41.
Butz DE, Li G, Cook ME. T10,c12 Conjugated Linoleic Acid Induces Compensatory Growth After Immune Challenge. J Nutr Biochem. 2006;17(11):735-41. PubMed PMID: 16517148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. AU - Butz,Daniel E, AU - Li,Guangming, AU - Cook,Mark E, Y1 - 2006/01/19/ PY - 2005/10/20/received PY - 2005/12/19/revised PY - 2005/12/20/accepted PY - 2006/3/7/pubmed PY - 2006/12/9/medline PY - 2006/3/7/entrez SP - 735 EP - 41 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 17 IS - 11 N2 - Previous work demonstrated that feeding commercial preparations of conjugated linoleic acid (CLA) [a 50:50 mixture of c9,t11 and t10,c12 CLA (cCLA)] partially overcame lipopolysaccharide (LPS)-induced growth depression. The objective of this study was to determine which CLA isomer was responsible for the reduction of LPS-induced growth depression. Dietary cCLA supplementation for 3 weeks protected mice from LPS-induced weight loss 24 h after injection compared to mice fed isocaloric and isonitrogenous control diets supplemented with either corn oil (CO) or a mixture of CO and olive oil. Dietary c9,t11 or t10,c12 CLA led to body weight loss intermediate to controls and cCLA. After LPS-induced weight loss, the t10,c12 CLA fed mice regained weight faster than the control or c9,t11 CLA fed mice. Dietary t10,c12 CLA and cCLA reduced plasma tumor necrosis factor 2 h after LPS stimulation. While neither c9,t11 nor t10,c12 CLA isomers alone protected from immune-induced weight loss, the t10,c12 CLA isomer induced compensatory gain. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/16517148/t10c12_Conjugated_linoleic_acid_induces_compensatory_growth_after_immune_challenge_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(05)00321-9 DB - PRIME DP - Unbound Medicine ER -