Tags

Type your tag names separated by a space and hit enter

Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan.
Oncol Nurs Forum. 2006 Nov 03; 33(2):E36-43.ON

Abstract

PURPOSE/OBJECTIVES

To provide clinical insights into dosing and administration of IV busulfan, a conditioning agent for hematopoietic stem cell transplantation (HSCT).

DATA SOURCES

Review of published literature related to busulfan pretransplant conditioning using MEDLINE. Meeting abstracts, investigational protocols, and pharmaceutical manufacturers' package inserts also were reviewed.

DATA SYNTHESIS

Busulfan is an effective myeloablative conditioning agent for HSCT. The IV formulation increases dose assurance and the ability to target a therapeutic window. Therapeutic drug monitoring ensures that targeted blood levels are achieved, especially in children, thereby preventing underdosing, which can lead to disease progression or rejection, as well as overdosing, which can cause an increased risk of toxic side effects.

CONCLUSIONS

IV busulfan is a convenient, safe, and effective conditioning agent used in HSCT that has a predictable pharmacokinetic profile.

IMPLICATIONS FOR NURSING

An understanding of the pharmacokinetic principles underlying the relationship between the therapeutic window for busulfan and optimal HSCT outcomes will facilitate proper dosing and administration of IV busulfan.

Authors+Show Affiliations

Pediatric Blood and Marrow Transplant Program, University Hospitals of Cleveland, USA. vicki.fisher@uhhs.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

16518436

Citation

Fisher, Vicki L., et al. "Pretransplant Conditioning in Adults and Children: Dose Assurance With Intravenous Busulfan." Oncology Nursing Forum, vol. 33, no. 2, 2006, pp. E36-43.
Fisher VL, Barnes YJ, Nuss SL. Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan. Oncol Nurs Forum. 2006;33(2):E36-43.
Fisher, V. L., Barnes, Y. J., & Nuss, S. L. (2006). Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan. Oncology Nursing Forum, 33(2), E36-43.
Fisher VL, Barnes YJ, Nuss SL. Pretransplant Conditioning in Adults and Children: Dose Assurance With Intravenous Busulfan. Oncol Nurs Forum. 2006 Nov 3;33(2):E36-43. PubMed PMID: 16518436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan. AU - Fisher,Vicki L, AU - Barnes,Yvonne J, AU - Nuss,Suzanne L, Y1 - 2006/11/03/ PY - 2006/3/7/pubmed PY - 2006/5/24/medline PY - 2006/3/7/entrez SP - E36 EP - 43 JF - Oncology nursing forum JO - Oncol Nurs Forum VL - 33 IS - 2 N2 - PURPOSE/OBJECTIVES: To provide clinical insights into dosing and administration of IV busulfan, a conditioning agent for hematopoietic stem cell transplantation (HSCT). DATA SOURCES: Review of published literature related to busulfan pretransplant conditioning using MEDLINE. Meeting abstracts, investigational protocols, and pharmaceutical manufacturers' package inserts also were reviewed. DATA SYNTHESIS: Busulfan is an effective myeloablative conditioning agent for HSCT. The IV formulation increases dose assurance and the ability to target a therapeutic window. Therapeutic drug monitoring ensures that targeted blood levels are achieved, especially in children, thereby preventing underdosing, which can lead to disease progression or rejection, as well as overdosing, which can cause an increased risk of toxic side effects. CONCLUSIONS: IV busulfan is a convenient, safe, and effective conditioning agent used in HSCT that has a predictable pharmacokinetic profile. IMPLICATIONS FOR NURSING: An understanding of the pharmacokinetic principles underlying the relationship between the therapeutic window for busulfan and optimal HSCT outcomes will facilitate proper dosing and administration of IV busulfan. SN - 1538-0688 UR - https://www.unboundmedicine.com/medline/citation/16518436/Pretransplant_conditioning_in_adults_and_children:_dose_assurance_with_intravenous_busulfan_ L2 - https://store.ons.org/article/find?doi=10.1188/06.ONF.E36-E43 DB - PRIME DP - Unbound Medicine ER -