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Clearance of circulating Epstein-Barr virus DNA in children with acute malaria after antimalaria treatment.
J Infect Dis. 2006 Apr 01; 193(7):971-7.JI

Abstract

Children living in malaria-endemic regions have a high incidence of Burkitt lymphoma (BL), the etiology of which involves Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections. In the present study, we compared EBV DNA loads in plasma and saliva samples from Ugandan children with acute malaria (M+) at the time of diagnosis and 14 days after antimalaria treatment, children without malaria (M-), and children with BL. EBV DNA was detected, by real-time polymerase chain reaction, in 31% of the plasma and in 79% of the saliva samples from children in the M+ group. Antimalaria treatment led to clearance of plasma viral load in 85% of the cases but did not affect the levels in saliva. There was a significant difference in plasma EBV loads across the groups. The lowest levels were detected in samples from the M- group, increased levels were detected in samples from the M+ group, and levels reached the highest values in samples from children with BL. The same trend was evident in the frequency and levels of anti-BZLF1 antibodies, which is indicative of viral reactivation. In the M+ group, the positive plasma samples clustered around 7-9 years of age, the peak incidence of BL. The clearance of circulating EBV after antimalaria treatment suggests a direct relationship between active malaria infection and viral reactivation.

Authors+Show Affiliations

Center for Infectious Medicine, Karolinska University Hospital--Huddinge, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16518759

Citation

Donati, Daria, et al. "Clearance of Circulating Epstein-Barr Virus DNA in Children With Acute Malaria After Antimalaria Treatment." The Journal of Infectious Diseases, vol. 193, no. 7, 2006, pp. 971-7.
Donati D, Espmark E, Kironde F, et al. Clearance of circulating Epstein-Barr virus DNA in children with acute malaria after antimalaria treatment. J Infect Dis. 2006;193(7):971-7.
Donati, D., Espmark, E., Kironde, F., Mbidde, E. K., Kamya, M., Lundkvist, A., Wahlgren, M., Bejarano, M. T., & Falk, K. I. (2006). Clearance of circulating Epstein-Barr virus DNA in children with acute malaria after antimalaria treatment. The Journal of Infectious Diseases, 193(7), 971-7.
Donati D, et al. Clearance of Circulating Epstein-Barr Virus DNA in Children With Acute Malaria After Antimalaria Treatment. J Infect Dis. 2006 Apr 1;193(7):971-7. PubMed PMID: 16518759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clearance of circulating Epstein-Barr virus DNA in children with acute malaria after antimalaria treatment. AU - Donati,Daria, AU - Espmark,Eva, AU - Kironde,Fred, AU - Mbidde,Edward Katongole, AU - Kamya,Moses, AU - Lundkvist,Ake, AU - Wahlgren,Mats, AU - Bejarano,Maria Teresa, AU - Falk,Kerstin I, Y1 - 2006/03/01/ PY - 2005/06/28/received PY - 2005/10/26/accepted PY - 2006/3/7/pubmed PY - 2006/4/18/medline PY - 2006/3/7/entrez SP - 971 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 193 IS - 7 N2 - Children living in malaria-endemic regions have a high incidence of Burkitt lymphoma (BL), the etiology of which involves Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections. In the present study, we compared EBV DNA loads in plasma and saliva samples from Ugandan children with acute malaria (M+) at the time of diagnosis and 14 days after antimalaria treatment, children without malaria (M-), and children with BL. EBV DNA was detected, by real-time polymerase chain reaction, in 31% of the plasma and in 79% of the saliva samples from children in the M+ group. Antimalaria treatment led to clearance of plasma viral load in 85% of the cases but did not affect the levels in saliva. There was a significant difference in plasma EBV loads across the groups. The lowest levels were detected in samples from the M- group, increased levels were detected in samples from the M+ group, and levels reached the highest values in samples from children with BL. The same trend was evident in the frequency and levels of anti-BZLF1 antibodies, which is indicative of viral reactivation. In the M+ group, the positive plasma samples clustered around 7-9 years of age, the peak incidence of BL. The clearance of circulating EBV after antimalaria treatment suggests a direct relationship between active malaria infection and viral reactivation. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16518759/Clearance_of_circulating_Epstein_Barr_virus_DNA_in_children_with_acute_malaria_after_antimalaria_treatment_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/500839 DB - PRIME DP - Unbound Medicine ER -