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Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction.
Clin Chem Lab Med. 2006; 44(3):274-81.CC

Abstract

BACKGROUND

Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease.

METHODS

We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls. APOE exon 4 and LPL S447X genotypes were determined.

RESULTS

APOE epsilon2 and epsilon4 homozygotes were increased in stroke (4.5% vs. 1.0%, p = 0.008), while in myocardial infarction the epsilon4 allele was increased (12.6% vs. 9.5%, p = 0.006) but epsilon2 was decreased (3.7% vs. 12.1%, p = 0.000006). For subjects with either APOE epsilon2 or epsilon4 alleles, LPL X alleles were increased in vascular disease (OR = 2.2, p = 0.01). LPL X alleles displayed opposite tendencies toward association with disease when subjects were divided by sex, smoking, or APOE genotype. Meta-analysis and regression analysis of previous studies supported the sex and smoking dichotomies.

CONCLUSION

This is the first report of an association of vascular disease with an interaction of APOE exon 4 and LPL S447X genotypes. Therefore, APOE genotypes and LPL S447X interactions with apoE, sex, and smoking may affect the risk of myocardial infarction and ischemic stroke.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong. lwbaum@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16519597

Citation

Baum, Larry, et al. "Associations of Apolipoprotein E Exon 4 and Lipoprotein Lipase S447X Polymorphisms With Acute Ischemic Stroke and Myocardial Infarction." Clinical Chemistry and Laboratory Medicine, vol. 44, no. 3, 2006, pp. 274-81.
Baum L, Ng HK, Wong KS, et al. Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction. Clin Chem Lab Med. 2006;44(3):274-81.
Baum, L., Ng, H. K., Wong, K. S., Tomlinson, B., Rainer, T. H., Chen, X., Cheung, W. S., Tang, J., Tam, W. W., Goggins, W., Tong, C. S., Chan, D. K., Thomas, G. N., Chook, P., & Woo, K. S. (2006). Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction. Clinical Chemistry and Laboratory Medicine, 44(3), 274-81.
Baum L, et al. Associations of Apolipoprotein E Exon 4 and Lipoprotein Lipase S447X Polymorphisms With Acute Ischemic Stroke and Myocardial Infarction. Clin Chem Lab Med. 2006;44(3):274-81. PubMed PMID: 16519597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction. AU - Baum,Larry, AU - Ng,Ho Keung, AU - Wong,Ka Sing, AU - Tomlinson,Brian, AU - Rainer,Timothy Hudson, AU - Chen,Xiangyan, AU - Cheung,Wing Sze, AU - Tang,Jinling, AU - Tam,Wilson Wai San, AU - Goggins,William, AU - Tong,Cindy See Wai, AU - Chan,Daniel Kam Yin, AU - Thomas,G Neil, AU - Chook,Ping, AU - Woo,Kam Sang, PY - 2006/3/8/pubmed PY - 2006/6/9/medline PY - 2006/3/8/entrez SP - 274 EP - 81 JF - Clinical chemistry and laboratory medicine JO - Clin Chem Lab Med VL - 44 IS - 3 N2 - BACKGROUND: Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease. METHODS: We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls. APOE exon 4 and LPL S447X genotypes were determined. RESULTS: APOE epsilon2 and epsilon4 homozygotes were increased in stroke (4.5% vs. 1.0%, p = 0.008), while in myocardial infarction the epsilon4 allele was increased (12.6% vs. 9.5%, p = 0.006) but epsilon2 was decreased (3.7% vs. 12.1%, p = 0.000006). For subjects with either APOE epsilon2 or epsilon4 alleles, LPL X alleles were increased in vascular disease (OR = 2.2, p = 0.01). LPL X alleles displayed opposite tendencies toward association with disease when subjects were divided by sex, smoking, or APOE genotype. Meta-analysis and regression analysis of previous studies supported the sex and smoking dichotomies. CONCLUSION: This is the first report of an association of vascular disease with an interaction of APOE exon 4 and LPL S447X genotypes. Therefore, APOE genotypes and LPL S447X interactions with apoE, sex, and smoking may affect the risk of myocardial infarction and ischemic stroke. SN - 1434-6621 UR - https://www.unboundmedicine.com/medline/citation/16519597/Associations_of_apolipoprotein_E_exon_4_and_lipoprotein_lipase_S447X_polymorphisms_with_acute_ischemic_stroke_and_myocardial_infarction_ L2 - https://www.degruyter.com/document/doi/10.1515/CCLM.2006.047 DB - PRIME DP - Unbound Medicine ER -