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Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra.
Eur J Neurosci 2006; 23(4):1063-70EJ

Abstract

The excitability of dopaminergic (DA) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the substantia nigra pars compacta, and VGLUT3 decorates a synapse population distinct from those marked by vesicular glutamate transporters 1 and 2. VGLUT3-ir nerve endings form asymmetric terminals on DA neurons. Retrograde tracing suggests the superior colliculus as an origin of excitatory VGLUT3-ir afferents. Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra.

Authors+Show Affiliations

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16519671

Citation

Martín-Ibañez, Raquel, et al. "Vesicular Glutamate Transporter 3 (VGLUT3) Identifies Spatially Segregated Excitatory Terminals in the Rat Substantia Nigra." The European Journal of Neuroscience, vol. 23, no. 4, 2006, pp. 1063-70.
Martín-Ibañez R, Jenstad M, Berghuis P, et al. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci. 2006;23(4):1063-70.
Martín-Ibañez, R., Jenstad, M., Berghuis, P., Edwards, R. H., Hioki, H., Kaneko, T., ... Harkany, T. (2006). Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. The European Journal of Neuroscience, 23(4), pp. 1063-70.
Martín-Ibañez R, et al. Vesicular Glutamate Transporter 3 (VGLUT3) Identifies Spatially Segregated Excitatory Terminals in the Rat Substantia Nigra. Eur J Neurosci. 2006;23(4):1063-70. PubMed PMID: 16519671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. AU - Martín-Ibañez,Raquel, AU - Jenstad,Monica, AU - Berghuis,Paul, AU - Edwards,Robert H, AU - Hioki,Hiroyuki, AU - Kaneko,Takeshi, AU - Mulder,Jan, AU - Canals,Josep M, AU - Ernfors,Patrik, AU - Chaudhry,Farrukh A, AU - Harkany,Tibor, PY - 2006/3/8/pubmed PY - 2006/5/10/medline PY - 2006/3/8/entrez SP - 1063 EP - 70 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 23 IS - 4 N2 - The excitability of dopaminergic (DA) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the substantia nigra pars compacta, and VGLUT3 decorates a synapse population distinct from those marked by vesicular glutamate transporters 1 and 2. VGLUT3-ir nerve endings form asymmetric terminals on DA neurons. Retrograde tracing suggests the superior colliculus as an origin of excitatory VGLUT3-ir afferents. Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16519671/Vesicular_glutamate_transporter_3__VGLUT3__identifies_spatially_segregated_excitatory_terminals_in_the_rat_substantia_nigra_ L2 - https://doi.org/10.1111/j.1460-9568.2006.04601.x DB - PRIME DP - Unbound Medicine ER -