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The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study.
J Herb Pharmacother. 2005; 5(3):87-96.JH

Abstract

Aegle marmelos Correa. (Bael) fruit exhibit antidiabetic, antihyperlipidaemic and antioxidant properties. This study was designed to elucidate the protective effect of an aqueous extract of Aegle marmelos fruits on the histopathology of the pancreas in streptozotocin-induced diabetic rats. Oral administration of Aegle marmelos fruit extract at doses of 125 and 250 mg/kg twice daily to diabetic rats for a period of 30 days resulted in a significant increase in body weight, weight of the pancreas and insulin levels associated with a significant decrease in fasting blood glucose levels. The fruit extract treated groups showed improved functional state of the pancreatic ss-cells and partially reversed the damage caused by streptozotocin to the pancreatic islets. The findings of our study indicate that Aegle marmelos fruit extract exhibits protective effects on the pancreas. The effects observed in the fruit extract treated animals were better those in animals treated with glibenclamide (300 microg/kg).

Authors+Show Affiliations

Department of Biochemistry, Annamalai Nagar, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16520300

Citation

Kamalakkannan, N, and P Stanely Mainzen Prince. "The Effect of Aegle Marmelos Fruit Extract in Streptozotocin Diabetes: a Histopathological Study." Journal of Herbal Pharmacotherapy, vol. 5, no. 3, 2005, pp. 87-96.
Kamalakkannan N, Prince PS. The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study. J Herb Pharmacother. 2005;5(3):87-96.
Kamalakkannan, N., & Prince, P. S. (2005). The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study. Journal of Herbal Pharmacotherapy, 5(3), 87-96.
Kamalakkannan N, Prince PS. The Effect of Aegle Marmelos Fruit Extract in Streptozotocin Diabetes: a Histopathological Study. J Herb Pharmacother. 2005;5(3):87-96. PubMed PMID: 16520300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study. AU - Kamalakkannan,N, AU - Prince,P Stanely Mainzen, PY - 2006/3/8/pubmed PY - 2006/7/28/medline PY - 2006/3/8/entrez SP - 87 EP - 96 JF - Journal of herbal pharmacotherapy JO - J Herb Pharmacother VL - 5 IS - 3 N2 - Aegle marmelos Correa. (Bael) fruit exhibit antidiabetic, antihyperlipidaemic and antioxidant properties. This study was designed to elucidate the protective effect of an aqueous extract of Aegle marmelos fruits on the histopathology of the pancreas in streptozotocin-induced diabetic rats. Oral administration of Aegle marmelos fruit extract at doses of 125 and 250 mg/kg twice daily to diabetic rats for a period of 30 days resulted in a significant increase in body weight, weight of the pancreas and insulin levels associated with a significant decrease in fasting blood glucose levels. The fruit extract treated groups showed improved functional state of the pancreatic ss-cells and partially reversed the damage caused by streptozotocin to the pancreatic islets. The findings of our study indicate that Aegle marmelos fruit extract exhibits protective effects on the pancreas. The effects observed in the fruit extract treated animals were better those in animals treated with glibenclamide (300 microg/kg). SN - 1522-8940 UR - https://www.unboundmedicine.com/medline/citation/16520300/The_effect_of_Aegle_marmelos_fruit_extract_in_streptozotocin_diabetes:_a_histopathological_study_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -