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Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men.

Abstract

BACKGROUND

Recent epidemiologic studies have generally reported a modest inverse association between calcium intake and the risk of colorectal cancer. However, findings pertaining to specific subsites in the colorectum have been conflicting.

OBJECTIVE

Our objective was to prospectively examine the relations between intakes of calcium and dairy foods and the risk of colorectal cancer, overall and by anatomic subsite, in men from the Cohort of Swedish Men.

DESIGN

In 1997, 45 306 men aged 45-79 y and without a history of cancer completed a food-frequency questionnaire. The men were followed through 31 December 2004.

RESULTS

During a mean follow-up of 6.7 y, we ascertained 449 incident cases of colorectal cancer. After adjustment for age and other known or potential risk factors, the multivariate rate ratio (RR) of colorectal cancer for men in the highest quartile of total calcium intake compared with those in the lowest quartile was 0.68 (95% CI: 0.51, 0.91; P for trend = 0.01). A high consumption of dairy foods was also associated with a lower risk of colorectal cancer. The multivariate RR of colorectal cancer for > or = 7 servings/d of total dairy foods compared with <2 servings/d was 0.46 (0.30, 0.71; P for trend = 0.01). For cancer subsites, the corresponding RRs were 0.37 (0.16, 0.88) for proximal colon, 0.43 (0.20, 0.93) for distal colon, and 0.48 (0.23, 0.99) for rectum.

CONCLUSION

Our findings provide support for inverse associations between intakes of calcium and dairy foods and the risk of colorectal cancer.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se

    , , ,

    Source

    The American journal of clinical nutrition 83:3 2006 Mar pg 667-73; quiz 728-9

    MeSH

    Aged
    Anticarcinogenic Agents
    Calcium, Dietary
    Cohort Studies
    Colorectal Neoplasms
    Dairy Products
    Diet
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16522915

    Citation

    Larsson, Susanna C., et al. "Calcium and Dairy Food Intakes Are Inversely Associated With Colorectal Cancer Risk in the Cohort of Swedish Men." The American Journal of Clinical Nutrition, vol. 83, no. 3, 2006, pp. 667-73; quiz 728-9.
    Larsson SC, Bergkvist L, Rutegård J, et al. Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men. Am J Clin Nutr. 2006;83(3):667-73; quiz 728-9.
    Larsson, S. C., Bergkvist, L., Rutegård, J., Giovannucci, E., & Wolk, A. (2006). Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men. The American Journal of Clinical Nutrition, 83(3), pp. 667-73; quiz 728-9.
    Larsson SC, et al. Calcium and Dairy Food Intakes Are Inversely Associated With Colorectal Cancer Risk in the Cohort of Swedish Men. Am J Clin Nutr. 2006;83(3):667-73; quiz 728-9. PubMed PMID: 16522915.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men. AU - Larsson,Susanna C, AU - Bergkvist,Leif, AU - Rutegård,Jörgen, AU - Giovannucci,Edward, AU - Wolk,Alicja, PY - 2006/3/9/pubmed PY - 2006/4/12/medline PY - 2006/3/9/entrez SP - 667-73; quiz 728-9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 83 IS - 3 N2 - BACKGROUND: Recent epidemiologic studies have generally reported a modest inverse association between calcium intake and the risk of colorectal cancer. However, findings pertaining to specific subsites in the colorectum have been conflicting. OBJECTIVE: Our objective was to prospectively examine the relations between intakes of calcium and dairy foods and the risk of colorectal cancer, overall and by anatomic subsite, in men from the Cohort of Swedish Men. DESIGN: In 1997, 45 306 men aged 45-79 y and without a history of cancer completed a food-frequency questionnaire. The men were followed through 31 December 2004. RESULTS: During a mean follow-up of 6.7 y, we ascertained 449 incident cases of colorectal cancer. After adjustment for age and other known or potential risk factors, the multivariate rate ratio (RR) of colorectal cancer for men in the highest quartile of total calcium intake compared with those in the lowest quartile was 0.68 (95% CI: 0.51, 0.91; P for trend = 0.01). A high consumption of dairy foods was also associated with a lower risk of colorectal cancer. The multivariate RR of colorectal cancer for > or = 7 servings/d of total dairy foods compared with <2 servings/d was 0.46 (0.30, 0.71; P for trend = 0.01). For cancer subsites, the corresponding RRs were 0.37 (0.16, 0.88) for proximal colon, 0.43 (0.20, 0.93) for distal colon, and 0.48 (0.23, 0.99) for rectum. CONCLUSION: Our findings provide support for inverse associations between intakes of calcium and dairy foods and the risk of colorectal cancer. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16522915/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn.83.3.667 DB - PRIME DP - Unbound Medicine ER -