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Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population.
Eur J Cancer Prev. 2006 Apr; 15(2):158-64.EJ

Abstract

Animal and laboratory studies suggest that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) may reduce prostate cancer risk. The aim of this study was to investigate the association between NSAID use and prostate cancer in a high-risk population. We included 1299 men who were referred to our university's prostate cancer detection clinic for prostate biopsy between January 1999 and July 2003. Before transrectal ultrasonography and prostate biopsy, all men completed a self-administered questionnaire that included questions on drug use in the preceding 5 years. On average, NSAID users were older than non-users but there was no significant difference in mean baseline prostate-specific antigen (PSA). Four hundred and ninety-four (38%) had biopsy-confirmed prostate cancer. After adjustment for age, family history of prostate cancer and other potential confounders, use of aspirin was associated with a 42% reduction in the odds of prostate cancer detection [95% confidence interval (CI) 0.36-0.91]. Among cases, regular use of NSAIDs was inversely related to the risk of detection of more poorly differentiated cancers and cancers with higher percentage core involvement. These findings support other epidemiological and experimental evidence that suggests that aspirin may be useful in prostate cancer prevention. Further observational studies with adequate case definition and exposure measurements and careful adjustment for detection bias are warranted.

Authors+Show Affiliations

Department of Oncology, McGill University, Montreal, Canada. Salah_mahmud@umanitoba.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16523013

Citation

Mahmud, Salaheddin M., et al. "Non-steroidal Anti-inflammatory Drug Use and Prostate Cancer in a High-risk Population." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 15, no. 2, 2006, pp. 158-64.
Mahmud SM, Tanguay S, Bégin LR, et al. Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population. Eur J Cancer Prev. 2006;15(2):158-64.
Mahmud, S. M., Tanguay, S., Bégin, L. R., Franco, E. L., & Aprikian, A. G. (2006). Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 15(2), 158-64.
Mahmud SM, et al. Non-steroidal Anti-inflammatory Drug Use and Prostate Cancer in a High-risk Population. Eur J Cancer Prev. 2006;15(2):158-64. PubMed PMID: 16523013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population. AU - Mahmud,Salaheddin M, AU - Tanguay,Simon, AU - Bégin,Louis R, AU - Franco,Eduardo L, AU - Aprikian,Armen G, PY - 2006/3/9/pubmed PY - 2006/8/31/medline PY - 2006/3/9/entrez SP - 158 EP - 64 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 15 IS - 2 N2 - Animal and laboratory studies suggest that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) may reduce prostate cancer risk. The aim of this study was to investigate the association between NSAID use and prostate cancer in a high-risk population. We included 1299 men who were referred to our university's prostate cancer detection clinic for prostate biopsy between January 1999 and July 2003. Before transrectal ultrasonography and prostate biopsy, all men completed a self-administered questionnaire that included questions on drug use in the preceding 5 years. On average, NSAID users were older than non-users but there was no significant difference in mean baseline prostate-specific antigen (PSA). Four hundred and ninety-four (38%) had biopsy-confirmed prostate cancer. After adjustment for age, family history of prostate cancer and other potential confounders, use of aspirin was associated with a 42% reduction in the odds of prostate cancer detection [95% confidence interval (CI) 0.36-0.91]. Among cases, regular use of NSAIDs was inversely related to the risk of detection of more poorly differentiated cancers and cancers with higher percentage core involvement. These findings support other epidemiological and experimental evidence that suggests that aspirin may be useful in prostate cancer prevention. Further observational studies with adequate case definition and exposure measurements and careful adjustment for detection bias are warranted. SN - 0959-8278 UR - https://www.unboundmedicine.com/medline/citation/16523013/Non_steroidal_anti_inflammatory_drug_use_and_prostate_cancer_in_a_high_risk_population_ L2 - http://dx.doi.org/10.1097/01.cej.0000197451.02604.25 DB - PRIME DP - Unbound Medicine ER -