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Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease.
Psychiatry Res 2006; 146(3):251-61PR

Abstract

Magnetic resonance imaging (MRI) is showing increased utility in examining medial temporal lobe atrophy and its relationship to memory performance in Alzheimer's disease (AD). We studied 56 AD patients and 42 older healthy subjects with neuropsychological assessment and MRI. Hippocampal and amygdaloid volumes (normalized to intracranial volume) were contrasted between AD patients and healthy controls and correlated with neuropsychological performance. Comparisons between AD patients and healthy controls revealed highly significant differences in the normalized volume of hippocampus and amygdala by analysis of covariance. Group differences tended to be at least as large for amygdaloid as hippocampal volume, including when the subset of AD patients with the mildest symptoms was considered separately. Within the AD group, performance on the Memory-Orientation subscale of the Alzheimer's Disease Assessment Scale-Cognition (ADAS-Cog) was significantly correlated with normalized amygdaloid volume but not with normalized hippocampal volume. Other ADAS-Cog subscales (Language, Praxis) were uncorrelated with either volume. In the healthy control sample, neither hippocampal nor amygdaloid volumes were significant predictors of any neuropsychological measure. While a substantial literature continues to justify the focus on the hippocampus in MRI studies of AD, these results suggest that the amygdala should receive similar attention, including in studies of the prodromal stages of AD.

Authors+Show Affiliations

Alzheimer's Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, One Church Street, New Haven, CT 06510, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16524704

Citation

Basso, Michael, et al. "Volumetry of Amygdala and Hippocampus and Memory Performance in Alzheimer's Disease." Psychiatry Research, vol. 146, no. 3, 2006, pp. 251-61.
Basso M, Yang J, Warren L, et al. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Res. 2006;146(3):251-61.
Basso, M., Yang, J., Warren, L., MacAvoy, M. G., Varma, P., Bronen, R. A., & van Dyck, C. H. (2006). Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research, 146(3), pp. 251-61.
Basso M, et al. Volumetry of Amygdala and Hippocampus and Memory Performance in Alzheimer's Disease. Psychiatry Res. 2006 Apr 30;146(3):251-61. PubMed PMID: 16524704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. AU - Basso,Michael, AU - Yang,John, AU - Warren,Lauren, AU - MacAvoy,Martha G, AU - Varma,Pradeep, AU - Bronen,Richard A, AU - van Dyck,Christopher H, Y1 - 2006/03/09/ PY - 2005/07/30/received PY - 2006/01/03/revised PY - 2006/01/08/accepted PY - 2006/3/10/pubmed PY - 2006/8/11/medline PY - 2006/3/10/entrez SP - 251 EP - 61 JF - Psychiatry research JO - Psychiatry Res VL - 146 IS - 3 N2 - Magnetic resonance imaging (MRI) is showing increased utility in examining medial temporal lobe atrophy and its relationship to memory performance in Alzheimer's disease (AD). We studied 56 AD patients and 42 older healthy subjects with neuropsychological assessment and MRI. Hippocampal and amygdaloid volumes (normalized to intracranial volume) were contrasted between AD patients and healthy controls and correlated with neuropsychological performance. Comparisons between AD patients and healthy controls revealed highly significant differences in the normalized volume of hippocampus and amygdala by analysis of covariance. Group differences tended to be at least as large for amygdaloid as hippocampal volume, including when the subset of AD patients with the mildest symptoms was considered separately. Within the AD group, performance on the Memory-Orientation subscale of the Alzheimer's Disease Assessment Scale-Cognition (ADAS-Cog) was significantly correlated with normalized amygdaloid volume but not with normalized hippocampal volume. Other ADAS-Cog subscales (Language, Praxis) were uncorrelated with either volume. In the healthy control sample, neither hippocampal nor amygdaloid volumes were significant predictors of any neuropsychological measure. While a substantial literature continues to justify the focus on the hippocampus in MRI studies of AD, these results suggest that the amygdala should receive similar attention, including in studies of the prodromal stages of AD. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/16524704/Volumetry_of_amygdala_and_hippocampus_and_memory_performance_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(06)00008-4 DB - PRIME DP - Unbound Medicine ER -