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Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy.
Biosens Bioelectron. 2006 Dec 15; 22(5):598-604.BB

Abstract

The aim of this work was to evaluate the performance of a novel non-invasive continuous glucose-monitoring system based on impedance spectroscopy (IS) in patients with diabetes. Ten patients with type 1 diabetes (mean+/-S.D., age 28+/-8 years, BMI 24.2+/-3.2 kg/m(2) and HbA(1C) 7.3+/-1.6%) and five with type 2 diabetes (age 61+/-8 years, BMI 27.5+/-3.2 kg/m(2) and HbA(1C) 8.3+/-1.8%) took part in this study, which comprised a glucose clamp experiment followed by a 7-day outpatient evaluation. The measurements obtained by the NI-CGMD and the reference blood glucose-measuring techniques were evaluated using retrospective data evaluation procedures. Under less controlled outpatient conditions a correlation coefficient of r=0.640 and a standard error of prediction (SEP) of 45 mg dl(-1) with a total of 590 paired glucose measurements was found (versus r=0.926 and a SEP of 26 mg dl(-1) under controlled conditions). Clark error grid analyses (EGA) showed 56% of all values in zone A, 37% in B and 7% in C-E. In conclusion, these results indicate that IS in the used technical setting allows retrospective, continuous and truly non-invasive glucose monitoring under defined conditions for patients with diabetes. Technical advances and developments are needed to expand on this concept to bring the results from the outpatient study closer to those in the experimental section of the study. Further studies will not only help to evaluate the performance and limitations of using such a technique for non non-invasive glucose monitoring but also help to verify technical extensions towards a IS-based concept that offers improved performance under real life operating conditions.

Authors+Show Affiliations

Solianis Monitoring, 8050 Zurich, Switzerland. andreas.caduff@solianis.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

16524714

Citation

Caduff, A, et al. "Non-invasive Glucose Monitoring in Patients With Diabetes: a Novel System Based On Impedance Spectroscopy." Biosensors & Bioelectronics, vol. 22, no. 5, 2006, pp. 598-604.
Caduff A, Dewarrat F, Talary M, et al. Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy. Biosens Bioelectron. 2006;22(5):598-604.
Caduff, A., Dewarrat, F., Talary, M., Stalder, G., Heinemann, L., & Feldman, Y. (2006). Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy. Biosensors & Bioelectronics, 22(5), 598-604.
Caduff A, et al. Non-invasive Glucose Monitoring in Patients With Diabetes: a Novel System Based On Impedance Spectroscopy. Biosens Bioelectron. 2006 Dec 15;22(5):598-604. PubMed PMID: 16524714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy. AU - Caduff,A, AU - Dewarrat,F, AU - Talary,M, AU - Stalder,G, AU - Heinemann,L, AU - Feldman,Yu, Y1 - 2006/03/09/ PY - 2005/11/01/received PY - 2006/01/16/revised PY - 2006/01/24/accepted PY - 2006/3/10/pubmed PY - 2007/1/18/medline PY - 2006/3/10/entrez SP - 598 EP - 604 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 22 IS - 5 N2 - The aim of this work was to evaluate the performance of a novel non-invasive continuous glucose-monitoring system based on impedance spectroscopy (IS) in patients with diabetes. Ten patients with type 1 diabetes (mean+/-S.D., age 28+/-8 years, BMI 24.2+/-3.2 kg/m(2) and HbA(1C) 7.3+/-1.6%) and five with type 2 diabetes (age 61+/-8 years, BMI 27.5+/-3.2 kg/m(2) and HbA(1C) 8.3+/-1.8%) took part in this study, which comprised a glucose clamp experiment followed by a 7-day outpatient evaluation. The measurements obtained by the NI-CGMD and the reference blood glucose-measuring techniques were evaluated using retrospective data evaluation procedures. Under less controlled outpatient conditions a correlation coefficient of r=0.640 and a standard error of prediction (SEP) of 45 mg dl(-1) with a total of 590 paired glucose measurements was found (versus r=0.926 and a SEP of 26 mg dl(-1) under controlled conditions). Clark error grid analyses (EGA) showed 56% of all values in zone A, 37% in B and 7% in C-E. In conclusion, these results indicate that IS in the used technical setting allows retrospective, continuous and truly non-invasive glucose monitoring under defined conditions for patients with diabetes. Technical advances and developments are needed to expand on this concept to bring the results from the outpatient study closer to those in the experimental section of the study. Further studies will not only help to evaluate the performance and limitations of using such a technique for non non-invasive glucose monitoring but also help to verify technical extensions towards a IS-based concept that offers improved performance under real life operating conditions. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/16524714/Non_invasive_glucose_monitoring_in_patients_with_diabetes:_a_novel_system_based_on_impedance_spectroscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(06)00038-8 DB - PRIME DP - Unbound Medicine ER -