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[The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina].
Anadolu Kardiyol Derg. 2006 Mar; 6(1):13-7.AK

Abstract

OBJECTIVE

The aim of this study is to compare lipoprotein (a) [Lp(a)] levels in patients with low and high risk unstable angina pectoris, which is defined according to the cardiac troponin-I (Tn-I) levels and to investigate their relation with myocardial damage.

METHODS

From patients with chest pain; venous blood samples were collected for measuring serum Lp(a) and C-reactive protein (CRP) levels on admission and serum cTn-I levels 12 and 24 hours after admission. Fifty-nine patients with serum cTn-I levels <1.0 ng/ml were assigned as negative unstable angina group and 53 patients with serum cTn-I levels >or=1.0 ng/ml were assigned as positive unstable angina groups, respectively. Severity of coronary artery disease was determined by angiography in all patients.

RESULTS

Compared with cTn-I negative group, Lp(a) levels were significantly higher in cTn-I positive group (52.9+/-6.0 mg/dl vs 15.7+/-2.5 mg/dl, p<0.0001). There was a significant correlation between Lp(a) and cTn-I levels (r=0.870, p=0.0001). We could not establish any correlation between Lp(a) levels and Gensini score or between multiple vessel disease and low density lipoprotein cholesterol levels (p>0.05). Also, there was no significant difference between cTn-I positive and negative groups with respect to Gensini score (p>0.05).

CONCLUSION

Increased Lp(a) levels and significant relation between Lp(a) and cTn-I levels support the opinion that Lp(a) can be a risk factor for plaque destabilization and thrombosis rather than severity of coronary artery disease in patients with high risk unstable angina. Furthermore, high levels of Lp(a) may be related with myocardial injury in patients with unstable angina.

Authors+Show Affiliations

Ondokuz Mayis Universitesi Tip Fakültesi, Kardiyoloji Anabilim Dali, Kurupelit 55139 - Samsun-Türkiye. drmeyaz@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

tur

PubMed ID

16524794

Citation

Yazici, Mustafa, et al. "[The Importance of Lipoprotein(a) in Pathogenesis of the High Risk Unstable Angina]." Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, vol. 6, no. 1, 2006, pp. 13-7.
Yazici M, Demircan S, Ibrahimli F, et al. [The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina]. Anadolu Kardiyol Derg. 2006;6(1):13-7.
Yazici, M., Demircan, S., Ibrahimli, F., Aksakal, E., Sahin, M., & Sağkan, O. (2006). [The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina]. Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, 6(1), 13-7.
Yazici M, et al. [The Importance of Lipoprotein(a) in Pathogenesis of the High Risk Unstable Angina]. Anadolu Kardiyol Derg. 2006;6(1):13-7. PubMed PMID: 16524794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The importance of lipoprotein(a) in pathogenesis of the high risk unstable angina]. AU - Yazici,Mustafa, AU - Demircan,Sabri, AU - Ibrahimli,Firdovsi, AU - Aksakal,Emre, AU - Sahin,Mahmut, AU - Sağkan,Olcay, PY - 2006/3/10/pubmed PY - 2006/6/9/medline PY - 2006/3/10/entrez SP - 13 EP - 7 JF - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology JO - Anadolu Kardiyol Derg VL - 6 IS - 1 N2 - OBJECTIVE: The aim of this study is to compare lipoprotein (a) [Lp(a)] levels in patients with low and high risk unstable angina pectoris, which is defined according to the cardiac troponin-I (Tn-I) levels and to investigate their relation with myocardial damage. METHODS: From patients with chest pain; venous blood samples were collected for measuring serum Lp(a) and C-reactive protein (CRP) levels on admission and serum cTn-I levels 12 and 24 hours after admission. Fifty-nine patients with serum cTn-I levels <1.0 ng/ml were assigned as negative unstable angina group and 53 patients with serum cTn-I levels >or=1.0 ng/ml were assigned as positive unstable angina groups, respectively. Severity of coronary artery disease was determined by angiography in all patients. RESULTS: Compared with cTn-I negative group, Lp(a) levels were significantly higher in cTn-I positive group (52.9+/-6.0 mg/dl vs 15.7+/-2.5 mg/dl, p<0.0001). There was a significant correlation between Lp(a) and cTn-I levels (r=0.870, p=0.0001). We could not establish any correlation between Lp(a) levels and Gensini score or between multiple vessel disease and low density lipoprotein cholesterol levels (p>0.05). Also, there was no significant difference between cTn-I positive and negative groups with respect to Gensini score (p>0.05). CONCLUSION: Increased Lp(a) levels and significant relation between Lp(a) and cTn-I levels support the opinion that Lp(a) can be a risk factor for plaque destabilization and thrombosis rather than severity of coronary artery disease in patients with high risk unstable angina. Furthermore, high levels of Lp(a) may be related with myocardial injury in patients with unstable angina. SN - 1302-8723 UR - https://www.unboundmedicine.com/medline/citation/16524794/[The_importance_of_lipoprotein_a__in_pathogenesis_of_the_high_risk_unstable_angina]_ L2 - http://www.anatoljcardiol.com/linkout/?PMID=16524794 DB - PRIME DP - Unbound Medicine ER -