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Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function.
Nephrol Dial Transplant. 2006 Jul; 21(7):1855-62.ND

Abstract

BACKGROUND

Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with chronic kidney disease (CKD). Recently, serum cystatin C was proposed as a new endogenous marker of GFR and in our study its diagnostic accuracy was compared with that of other markers of GFR.

METHODS

In this study, 164 patients with CKD stages 2-3 (GFR 30-89 ml/min/1.73 m2), who had performed 51Cr-labelled ethylenediaminetetra-acetic acid clearance, were enrolled. In each patient, serum creatinine and serum cystatin C were determined. Creatinine clearance was calculated using the Cockcroft-Gault (C&G) and the modification of diet in renal disease (MDRD) formulas.

RESULTS

The mean 51CrEDTA clearance was 57 ml/min/1.73 m2, the mean serum creatinine 149 micromol/l and the mean serum cystatin C 1.74 mg/l. We found significant correlation between 51CrEDTA clearance and serum creatinine (R = -0.666), serum cystatin C (R = -0.792), reciprocal of serum creatinine (R = 0.628), reciprocal of serum cystatin C (R = 0.753) and calculated creatinine clearance from the formulas C&G (R = 0.515) and MDRD formulas (R = 0.716). The receiver operating characteristic (ROC) curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C had a significantly higher diagnostic accuracy than serum creatinine (P = 0.04) and calculated creatinine clearance from the C&G formula (P < 0.0001), though only in female patients. No difference in diagnostic accuracy was found between serum cystatin C and creatinine clearance calculated from the MDRD formula.

CONCLUSIONS

Our results indicate that serum cystatin C is a reliable marker of GFR in patients with mildly to moderately impaired kidney function and has a higher diagnostic accuracy than serum creatinine and calculated creatinine clearance from the C&G formula in female patients.

Authors+Show Affiliations

Department of Nephrology, Clinical Department of Internal Medicine, Teaching Hospital Maribor, Maribor, Slovenia. Radovan.Hojs@sb-mb.siNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16524933

Citation

Hojs, Radovan, et al. "Serum Cystatin C as an Endogenous Marker of Renal Function in Patients With Mild to Moderate Impairment of Kidney Function." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 21, no. 7, 2006, pp. 1855-62.
Hojs R, Bevc S, Ekart R, et al. Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. Nephrol Dial Transplant. 2006;21(7):1855-62.
Hojs, R., Bevc, S., Ekart, R., Gorenjak, M., & Puklavec, L. (2006). Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 21(7), 1855-62.
Hojs R, et al. Serum Cystatin C as an Endogenous Marker of Renal Function in Patients With Mild to Moderate Impairment of Kidney Function. Nephrol Dial Transplant. 2006;21(7):1855-62. PubMed PMID: 16524933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. AU - Hojs,Radovan, AU - Bevc,Sebastjan, AU - Ekart,Robert, AU - Gorenjak,Maksimiljan, AU - Puklavec,Ludvik, Y1 - 2006/03/08/ PY - 2006/3/10/pubmed PY - 2007/2/3/medline PY - 2006/3/10/entrez SP - 1855 EP - 62 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 21 IS - 7 N2 - BACKGROUND: Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with chronic kidney disease (CKD). Recently, serum cystatin C was proposed as a new endogenous marker of GFR and in our study its diagnostic accuracy was compared with that of other markers of GFR. METHODS: In this study, 164 patients with CKD stages 2-3 (GFR 30-89 ml/min/1.73 m2), who had performed 51Cr-labelled ethylenediaminetetra-acetic acid clearance, were enrolled. In each patient, serum creatinine and serum cystatin C were determined. Creatinine clearance was calculated using the Cockcroft-Gault (C&G) and the modification of diet in renal disease (MDRD) formulas. RESULTS: The mean 51CrEDTA clearance was 57 ml/min/1.73 m2, the mean serum creatinine 149 micromol/l and the mean serum cystatin C 1.74 mg/l. We found significant correlation between 51CrEDTA clearance and serum creatinine (R = -0.666), serum cystatin C (R = -0.792), reciprocal of serum creatinine (R = 0.628), reciprocal of serum cystatin C (R = 0.753) and calculated creatinine clearance from the formulas C&G (R = 0.515) and MDRD formulas (R = 0.716). The receiver operating characteristic (ROC) curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C had a significantly higher diagnostic accuracy than serum creatinine (P = 0.04) and calculated creatinine clearance from the C&G formula (P < 0.0001), though only in female patients. No difference in diagnostic accuracy was found between serum cystatin C and creatinine clearance calculated from the MDRD formula. CONCLUSIONS: Our results indicate that serum cystatin C is a reliable marker of GFR in patients with mildly to moderately impaired kidney function and has a higher diagnostic accuracy than serum creatinine and calculated creatinine clearance from the C&G formula in female patients. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/16524933/Serum_cystatin_C_as_an_endogenous_marker_of_renal_function_in_patients_with_mild_to_moderate_impairment_of_kidney_function_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfl073 DB - PRIME DP - Unbound Medicine ER -