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Microsporidiosis in Venezuela: prevalence of intestinal microsporidiosis and its contribution to diarrhea in a group of human immunodeficiency virus-infected patients from Zulia State.
Am J Trop Med Hyg. 2006 Mar; 74(3):482-6.AJ

Abstract

Microsporidia are recognized as a cause of morbidity among patients infected with the human immunodeficiency virus (HIV). Infection rates for intestinal microsporidiosis in HIV-infected patients from Venezuela are unknown. To determine the prevalence and pathogenic role of microsporidia in these patients in northwestern Venezuela, a case control study was conducted in 103 outpatients (mean +/- SD age = 37.3 +/- 5.6 years). Microsporidia were detected using unconcentrated formalin-fixed stools examined by Weber's chromotrope-based staining method. For identification of coccidia, modified Ziehl-Neelsen carbolfuchsin staining of formalin-ether concentrates were used, and for other pathogenic parasites, iron hematoxylin-stained smears and formalin-ether concentrates were examined. Microsporidial infections were detected in 14 (13.6%) of 103 patients and 39 (37.9%) had other parasitic pathogens. No significant difference was noted in the occurrence of the infection in patients with diarrhea (13 of 74, 17.6%) and controls (1 of 29, 3.4%) (P = 0.118). Nevertheless, this result may be due to the small sample size (n = 14) of infected individuals. The proportions of other pathogens in patients with or without diarrhea were not significantly different (P = 0.828). Microsporidiosis is common among the HIV-infected population in northwestern Venezuela. However, its pathogenic role in these patients is uncertain and warrants further investigation.

Authors+Show Affiliations

Postgrado de Inmunología, Departamento de Salud Pública y Social, y Cátedra de Virología, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. leonorbonilla42@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16525110

Citation

Chacin-Bonilla, Leonor, et al. "Microsporidiosis in Venezuela: Prevalence of Intestinal Microsporidiosis and Its Contribution to Diarrhea in a Group of Human Immunodeficiency Virus-infected Patients From Zulia State." The American Journal of Tropical Medicine and Hygiene, vol. 74, no. 3, 2006, pp. 482-6.
Chacin-Bonilla L, Panunzio AP, Monsalve-Castillo FM, et al. Microsporidiosis in Venezuela: prevalence of intestinal microsporidiosis and its contribution to diarrhea in a group of human immunodeficiency virus-infected patients from Zulia State. Am J Trop Med Hyg. 2006;74(3):482-6.
Chacin-Bonilla, L., Panunzio, A. P., Monsalve-Castillo, F. M., Parra-Cepeda, I. E., & Martinez, R. (2006). Microsporidiosis in Venezuela: prevalence of intestinal microsporidiosis and its contribution to diarrhea in a group of human immunodeficiency virus-infected patients from Zulia State. The American Journal of Tropical Medicine and Hygiene, 74(3), 482-6.
Chacin-Bonilla L, et al. Microsporidiosis in Venezuela: Prevalence of Intestinal Microsporidiosis and Its Contribution to Diarrhea in a Group of Human Immunodeficiency Virus-infected Patients From Zulia State. Am J Trop Med Hyg. 2006;74(3):482-6. PubMed PMID: 16525110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microsporidiosis in Venezuela: prevalence of intestinal microsporidiosis and its contribution to diarrhea in a group of human immunodeficiency virus-infected patients from Zulia State. AU - Chacin-Bonilla,Leonor, AU - Panunzio,Amelia P, AU - Monsalve-Castillo,Francisca M, AU - Parra-Cepeda,Irene E, AU - Martinez,Rodrigo, PY - 2006/3/10/pubmed PY - 2006/4/28/medline PY - 2006/3/10/entrez SP - 482 EP - 6 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 74 IS - 3 N2 - Microsporidia are recognized as a cause of morbidity among patients infected with the human immunodeficiency virus (HIV). Infection rates for intestinal microsporidiosis in HIV-infected patients from Venezuela are unknown. To determine the prevalence and pathogenic role of microsporidia in these patients in northwestern Venezuela, a case control study was conducted in 103 outpatients (mean +/- SD age = 37.3 +/- 5.6 years). Microsporidia were detected using unconcentrated formalin-fixed stools examined by Weber's chromotrope-based staining method. For identification of coccidia, modified Ziehl-Neelsen carbolfuchsin staining of formalin-ether concentrates were used, and for other pathogenic parasites, iron hematoxylin-stained smears and formalin-ether concentrates were examined. Microsporidial infections were detected in 14 (13.6%) of 103 patients and 39 (37.9%) had other parasitic pathogens. No significant difference was noted in the occurrence of the infection in patients with diarrhea (13 of 74, 17.6%) and controls (1 of 29, 3.4%) (P = 0.118). Nevertheless, this result may be due to the small sample size (n = 14) of infected individuals. The proportions of other pathogens in patients with or without diarrhea were not significantly different (P = 0.828). Microsporidiosis is common among the HIV-infected population in northwestern Venezuela. However, its pathogenic role in these patients is uncertain and warrants further investigation. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/16525110/Microsporidiosis_in_Venezuela:_prevalence_of_intestinal_microsporidiosis_and_its_contribution_to_diarrhea_in_a_group_of_human_immunodeficiency_virus_infected_patients_from_Zulia_State_ L2 - http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=16525110 DB - PRIME DP - Unbound Medicine ER -