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Small-fiber neuropathy: answering the burning questions.
Sci Aging Knowledge Environ. 2006 Mar 08; 2006(6):pe7.SA

Abstract

Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a mystery because standard electrophysiologic tests for nerve injury do not detect small-fiber function. Inadequate ability to test for and diagnose small-fiber neuropathies has impeded patient care and research, but new tools offer promise. Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain.

Authors+Show Affiliations

Department of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. efink@partners.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16525192

Citation

Fink, Ezekiel, and Anne Louise Oaklander. "Small-fiber Neuropathy: Answering the Burning Questions." Science of Aging Knowledge Environment : SAGE KE, vol. 2006, no. 6, 2006, pp. pe7.
Fink E, Oaklander AL. Small-fiber neuropathy: answering the burning questions. Sci Aging Knowledge Environ. 2006;2006(6):pe7.
Fink, E., & Oaklander, A. L. (2006). Small-fiber neuropathy: answering the burning questions. Science of Aging Knowledge Environment : SAGE KE, 2006(6), pe7.
Fink E, Oaklander AL. Small-fiber Neuropathy: Answering the Burning Questions. Sci Aging Knowledge Environ. 2006 Mar 8;2006(6):pe7. PubMed PMID: 16525192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small-fiber neuropathy: answering the burning questions. AU - Fink,Ezekiel, AU - Oaklander,Anne Louise, Y1 - 2006/03/08/ PY - 2006/3/10/pubmed PY - 2006/3/29/medline PY - 2006/3/10/entrez SP - pe7 EP - pe7 JF - Science of aging knowledge environment : SAGE KE JO - Sci Aging Knowledge Environ VL - 2006 IS - 6 N2 - Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a mystery because standard electrophysiologic tests for nerve injury do not detect small-fiber function. Inadequate ability to test for and diagnose small-fiber neuropathies has impeded patient care and research, but new tools offer promise. Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain. SN - 1539-6150 UR - https://www.unboundmedicine.com/medline/citation/16525192/Small_fiber_neuropathy:_answering_the_burning_questions_ L2 - http://sageke.sciencemag.org/cgi/pmidlookup?view=long&pmid=16525192 DB - PRIME DP - Unbound Medicine ER -