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Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes.
J Org Chem. 2006 Mar 17; 71(6):2535-7.JO

Abstract

Under copper-free conditions and with Cs2CO3 as a base, PdCl2(PCy3)2 showed high catalytic activity for cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes in DMSO at 100-120 degrees C affording internal arylated alkynes in good to excellent yields.

Authors+Show Affiliations

Yi C
Department of Chemistry, Tsinghua University, Innovative Catalysis Program, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
Hua R
No affiliation info available

MeSH

AlkynesCatalysisHydrocarbons, ChlorinatedMolecular StructureOrganometallic CompoundsPalladiumStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16526813

Citation

Yi, Chenyi, and Ruimao Hua. "Efficient Copper-free PdCl2(PCy3)2-catalyzed Sonogashira Coupling of Aryl Chlorides With Terminal Alkynes." The Journal of Organic Chemistry, vol. 71, no. 6, 2006, pp. 2535-7.
Yi C, Hua R. Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes. J Org Chem. 2006;71(6):2535-7.
Yi, C., & Hua, R. (2006). Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes. The Journal of Organic Chemistry, 71(6), 2535-7.
Yi C, Hua R. Efficient Copper-free PdCl2(PCy3)2-catalyzed Sonogashira Coupling of Aryl Chlorides With Terminal Alkynes. J Org Chem. 2006 Mar 17;71(6):2535-7. PubMed PMID: 16526813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes. AU - Yi,Chenyi, AU - Hua,Ruimao, PY - 2006/3/11/pubmed PY - 2007/1/27/medline PY - 2006/3/11/entrez SP - 2535 EP - 7 JF - The Journal of organic chemistry JO - J Org Chem VL - 71 IS - 6 N2 - Under copper-free conditions and with Cs2CO3 as a base, PdCl2(PCy3)2 showed high catalytic activity for cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes in DMSO at 100-120 degrees C affording internal arylated alkynes in good to excellent yields. SN - 0022-3263 UR - https://www.unboundmedicine.com/medline/citation/16526813/Efficient_copper_free_PdCl2_PCy3_2_catalyzed_Sonogashira_coupling_of_aryl_chlorides_with_terminal_alkynes_ DB - PRIME DP - Unbound Medicine ER -