Tags

Type your tag names separated by a space and hit enter

Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
Virology. 2006 Jun 05; 349(2):335-46.V

Abstract

The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human respiratory coronavirus, the OC43 strain of human coronavirus (HCoV-OC43). First, primary cell cultures were used to determine the susceptibility of each type of neural cells to virus infection. Neurons were the target cells, undergoing degeneration during infection, in part due to apoptosis. Second, neuropathogenicity was investigated in susceptible mice. Intracerebral inoculation of HCoV-OC43 into BALB/c mice led to an acute encephalitis with neuronal cell death by necrosis and apoptosis. Infectious virus was apparently cleared from surviving animals, whereas viral RNA persisted for several months. Some of the animals surviving to acute encephalitis presented an abnormal limb clasping reflex and a decrease in motor activity starting several months post-infection. These results suggest that viral persistence could be associated with an increased neuronal degeneration leading to neuropathology and motor deficits in susceptible individuals.

Authors+Show Affiliations

Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, Québec, Canada H7V 1B7.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16527322

Citation

Jacomy, Hélène, et al. "Human Coronavirus OC43 Infection Induces Chronic Encephalitis Leading to Disabilities in BALB/C Mice." Virology, vol. 349, no. 2, 2006, pp. 335-46.
Jacomy H, Fragoso G, Almazan G, et al. Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology. 2006;349(2):335-46.
Jacomy, H., Fragoso, G., Almazan, G., Mushynski, W. E., & Talbot, P. J. (2006). Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology, 349(2), 335-46.
Jacomy H, et al. Human Coronavirus OC43 Infection Induces Chronic Encephalitis Leading to Disabilities in BALB/C Mice. Virology. 2006 Jun 5;349(2):335-46. PubMed PMID: 16527322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. AU - Jacomy,Hélène, AU - Fragoso,Gabriela, AU - Almazan,Guillermina, AU - Mushynski,Walter E, AU - Talbot,Pierre J, Y1 - 2006/03/09/ PY - 2005/11/08/received PY - 2006/01/11/revised PY - 2006/01/18/accepted PY - 2006/3/11/pubmed PY - 2006/7/15/medline PY - 2006/3/11/entrez SP - 335 EP - 46 JF - Virology JO - Virology VL - 349 IS - 2 N2 - The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human respiratory coronavirus, the OC43 strain of human coronavirus (HCoV-OC43). First, primary cell cultures were used to determine the susceptibility of each type of neural cells to virus infection. Neurons were the target cells, undergoing degeneration during infection, in part due to apoptosis. Second, neuropathogenicity was investigated in susceptible mice. Intracerebral inoculation of HCoV-OC43 into BALB/c mice led to an acute encephalitis with neuronal cell death by necrosis and apoptosis. Infectious virus was apparently cleared from surviving animals, whereas viral RNA persisted for several months. Some of the animals surviving to acute encephalitis presented an abnormal limb clasping reflex and a decrease in motor activity starting several months post-infection. These results suggest that viral persistence could be associated with an increased neuronal degeneration leading to neuropathology and motor deficits in susceptible individuals. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/16527322/Human_coronavirus_OC43_infection_induces_chronic_encephalitis_leading_to_disabilities_in_BALB/C_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(06)00038-9 DB - PRIME DP - Unbound Medicine ER -