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Multifactorial nature of male nocturia.
Urology. 2006 Mar; 67(3):541-4.U

Abstract

OBJECTIVES

To conduct a prospective study to determine the causes of nocturia in men.

METHODS

The study included 41 male patients (mean age 72.5 years) bothered by nocturia (two or more micturitions per night). Eleven asymptomatic young men (mean age 28.4 years) were enrolled as a control group. All completed a 3-day voiding diary. Daytime and nighttime urine samples were collected to determine osmolality and sodium and potassium levels. Urodynamic studies were performed for all patients with nocturia to evaluate for bladder outlet obstruction using the International Continence Society definition. Polysomnography was performed on selected patients to detect sleep apnea.

RESULTS

The average nighttime voiding frequency was 3.9 in the patients with nocturia. Nocturnal polyuria (NP) was found in 34 (82.9%) of 41 patients. In these patients, the nighttime urinary sodium excretion was significantly greater than the daytime excretion, with lower nighttime urine osmolality. In contrast, nighttime and daytime sodium excretion was not significantly different in patients without NP, and greater nighttime urine osmolality was noted in the patients without NP and the control group. Of the 41 patients, 24 (58.5%) had a small nocturnal bladder capacity, with detrusor overactivity in 14 of 24 patients. Eighteen patients (43.9%) had both NP and a small nocturnal bladder capacity. Another 18 patients had bladder outlet obstruction and NP. Two patients had sleep apnea.

CONCLUSIONS

Our observations have shown that a significant contributor to male nocturia is NP, which results from a disordered diurnal rhythm of sodium excretion and other unknown factors causing nocturnal urinary dilution. However, male nocturia can also be secondary to a combination of factors. Detailed workup is necessary to elucidate all causes.

Authors+Show Affiliations

Division of Urology, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16527575

Citation

Chang, Shyh-Chyi, et al. "Multifactorial Nature of Male Nocturia." Urology, vol. 67, no. 3, 2006, pp. 541-4.
Chang SC, Lin AT, Chen KK, et al. Multifactorial nature of male nocturia. Urology. 2006;67(3):541-4.
Chang, S. C., Lin, A. T., Chen, K. K., & Chang, L. S. (2006). Multifactorial nature of male nocturia. Urology, 67(3), 541-4.
Chang SC, et al. Multifactorial Nature of Male Nocturia. Urology. 2006;67(3):541-4. PubMed PMID: 16527575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifactorial nature of male nocturia. AU - Chang,Shyh-Chyi, AU - Lin,Alex T L, AU - Chen,Kuang-Kuo, AU - Chang,Luke S, PY - 2005/05/01/received PY - 2005/08/26/revised PY - 2005/09/26/accepted PY - 2006/3/11/pubmed PY - 2006/4/28/medline PY - 2006/3/11/entrez SP - 541 EP - 4 JF - Urology JO - Urology VL - 67 IS - 3 N2 - OBJECTIVES: To conduct a prospective study to determine the causes of nocturia in men. METHODS: The study included 41 male patients (mean age 72.5 years) bothered by nocturia (two or more micturitions per night). Eleven asymptomatic young men (mean age 28.4 years) were enrolled as a control group. All completed a 3-day voiding diary. Daytime and nighttime urine samples were collected to determine osmolality and sodium and potassium levels. Urodynamic studies were performed for all patients with nocturia to evaluate for bladder outlet obstruction using the International Continence Society definition. Polysomnography was performed on selected patients to detect sleep apnea. RESULTS: The average nighttime voiding frequency was 3.9 in the patients with nocturia. Nocturnal polyuria (NP) was found in 34 (82.9%) of 41 patients. In these patients, the nighttime urinary sodium excretion was significantly greater than the daytime excretion, with lower nighttime urine osmolality. In contrast, nighttime and daytime sodium excretion was not significantly different in patients without NP, and greater nighttime urine osmolality was noted in the patients without NP and the control group. Of the 41 patients, 24 (58.5%) had a small nocturnal bladder capacity, with detrusor overactivity in 14 of 24 patients. Eighteen patients (43.9%) had both NP and a small nocturnal bladder capacity. Another 18 patients had bladder outlet obstruction and NP. Two patients had sleep apnea. CONCLUSIONS: Our observations have shown that a significant contributor to male nocturia is NP, which results from a disordered diurnal rhythm of sodium excretion and other unknown factors causing nocturnal urinary dilution. However, male nocturia can also be secondary to a combination of factors. Detailed workup is necessary to elucidate all causes. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/16527575/Multifactorial_nature_of_male_nocturia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(05)01392-0 DB - PRIME DP - Unbound Medicine ER -